Hypochloremia: A Potential Indicator of Poor Outcomes in COVID-19 Article Swipe
Orçun Barkay
,
Faruk Karakeçili
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/medicina60091414
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/medicina60091414
Background: Coronavirus Disease-2019 (COVID-19) has posed formidable challenges to healthcare systems. Exploring novel biomarkers that can provide valuable prognostic insights, particularly in critically ill patients, has a significant importance. Against this backdrop, our study aims to elucidate the associations between serum chloride levels and clinical outcomes. Methods: A total of 499 patients were enrolled into the study. The serum chloride levels of patients upon hospital admission were recorded and then categorized into three groups (hypochloremia, normochloremia, and hyperchloremia) for the evaluation of clinical outcomes. Additionally, serum C-reactive protein, procalcitonin, and D-dimer measurements were recorded for further evaluation. Results: A total of 390 (78.1%) patients tested positive for COVID-19 via polymerase chain reaction testing. Non-contrast thorax computed tomography scans were indicative of COVID-19 compatibility for all patients. A total of 210 (42%) patients were female and 289 (58%) were male. A total of 214 (42.8%) patients necessitated tocilizumab intervention; 250 (50.1%) were at an intensive care unit (ICU), with 166 (66.4%) of them receiving tocilizumab. A total of 65 (13%) patients died, 40 (61.5%) of whom received tocilizumab; 41 (63%) were in the ICU. Serum chloride levels upon admission were markedly lower and elevated D-dimer levels were apparent in tocilizumab users, patients requiring ICU care, and patients who died. Conclusions: our findings provide robust evidence supporting the value of serum chloride levels as a prognostic biomarker in critically ill COVID-19 patients.
Related Topics
Concepts
Hypochloremia
Coronavirus disease 2019 (COVID-19)
2019-20 coronavirus outbreak
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Medicine
Virology
Hyponatremia
Outbreak
Internal medicine
Disease
Infectious disease (medical specialty)
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/medicina60091414
- https://www.mdpi.com/1648-9144/60/9/1414/pdf?version=1724929307
- OA Status
- gold
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401991779
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401991779Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/medicina60091414Digital Object Identifier
- Title
-
Hypochloremia: A Potential Indicator of Poor Outcomes in COVID-19Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-29Full publication date if available
- Authors
-
Orçun Barkay, Faruk KarakeçiliList of authors in order
- Landing page
-
https://doi.org/10.3390/medicina60091414Publisher landing page
- PDF URL
-
https://www.mdpi.com/1648-9144/60/9/1414/pdf?version=1724929307Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1648-9144/60/9/1414/pdf?version=1724929307Direct OA link when available
- Concepts
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Hypochloremia, Coronavirus disease 2019 (COVID-19), 2019-20 coronavirus outbreak, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Medicine, Virology, Hyponatremia, Outbreak, Internal medicine, Disease, Infectious disease (medical specialty)Top concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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