Hypotension and antiphlogistic potential of empagliflozin ocular film: swelling and release kinetics Article Swipe
Tanisha Das
,
Subrata Mallick
,
Sourajit Parida
,
Mouli Das
,
Rakesh Swain
,
Sk Habibullah
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.5599/admet.2941
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.5599/admet.2941
Background and Purpose: Empagliflozin (EMP) is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used for the management of type 2 diabetes mellitus. The danger of glaucoma in type 2 diabetes mellitus patients is known to be reduced using SGLT2 inhibitors. Empagliflozin is also believed to reduce the level of inflammatory markers. The present work has been undertaken for monitoring intraocular pressure and anti-inflammatory activity using the empagliflozin ocular film formulation. The effect of colloidal silicon dioxide upon the dynamics of swelling and drug release performance was also studied. Experimental Approach: Hydroxypropyl methylcellulose-based ocular film of empagliflozin was prepared, including silicon dioxide in different ratios as 1:0.00, 1:0.01, 1:0.02, 1:0.04, and 1:0.06 (namely, EMA0, EMA1, EMA2, EMA3 and EMA4, respectively) using casting and solvent evaporation. Swelling and drug release studies of the films were conducted in phosphate buffer solution (pH 7.4), and the kinetic mechanisms of swelling and drug release were evaluated. Intraocular pressure was measured after application of the film in the normotensive rabbit eye. Moreover, the anti-inflammatory effect was assessed using a rabbit ocular carrageenan-induced inflammation model. Key Results: Swelling behaviour followed Fickian mechanism in the order: EMA3
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- Type
- article
- Landing Page
- https://doi.org/10.5599/admet.2941
- https://pub.iapchem.org/ojs/index.php/admet/article/download/2941/2671
- OA Status
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- References
- 29
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W7106513431Canonical identifier for this work in OpenAlex
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https://doi.org/10.5599/admet.2941Digital Object Identifier
- Title
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Hypotension and antiphlogistic potential of empagliflozin ocular film: swelling and release kineticsWork title
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articleOpenAlex work type
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2025Year of publication
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2025-11-24Full publication date if available
- Authors
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Tanisha Das, Subrata Mallick, Sourajit Parida, Mouli Das, Rakesh Swain, Sk HabibullahList of authors in order
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https://doi.org/10.5599/admet.2941Publisher landing page
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https://pub.iapchem.org/ojs/index.php/admet/article/download/2941/2671Direct link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://pub.iapchem.org/ojs/index.php/admet/article/download/2941/2671Direct OA link when available
- Concepts
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Empagliflozin, Swelling, Intraocular pressure, Pharmacology, Silicon dioxide, Ocular hypertension, Medicine, Cornea, Chemistry, Glaucoma, Ophthalmology, Diffusion, Drug, Inflammation, AnesthesiaTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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| abstract_inverted_index.upon | 75 |
| abstract_inverted_index.used | 12, 262 |
| abstract_inverted_index.were | 131, 148 |
| abstract_inverted_index.with | 191, 223, 275 |
| abstract_inverted_index.work | 52 |
| abstract_inverted_index.(EMP) | 4 |
| abstract_inverted_index.7.4), | 138 |
| abstract_inverted_index.EMA0, | 111 |
| abstract_inverted_index.EMA1, | 112 |
| abstract_inverted_index.EMA2, | 113 |
| abstract_inverted_index.EMA3. | 192 |
| abstract_inverted_index.EMA4, | 116 |
| abstract_inverted_index.Films | 193 |
| abstract_inverted_index.SGLT2 | 37 |
| abstract_inverted_index.after | 154 |
| abstract_inverted_index.could | 260 |
| abstract_inverted_index.films | 130 |
| abstract_inverted_index.known | 32 |
| abstract_inverted_index.level | 46 |
| abstract_inverted_index.those | 201 |
| abstract_inverted_index.using | 36, 63, 118, 170 |
| abstract_inverted_index.(EMA3) | 213 |
| abstract_inverted_index.1:0.06 | 109 |
| abstract_inverted_index.buffer | 135 |
| abstract_inverted_index.danger | 22 |
| abstract_inverted_index.effect | 70, 167 |
| abstract_inverted_index.faster | 198 |
| abstract_inverted_index.manage | 264 |
| abstract_inverted_index.manner | 272 |
| abstract_inverted_index.model. | 176 |
| abstract_inverted_index.ocular | 66, 91, 173, 221, 253 |
| abstract_inverted_index.order: | 186 |
| abstract_inverted_index.rabbit | 162, 172 |
| abstract_inverted_index.ratios | 102 |
| abstract_inverted_index.reduce | 44 |
| abstract_inverted_index.showed | 197, 214 |
| abstract_inverted_index.tumour | 234 |
| abstract_inverted_index.(EMA0), | 204 |
| abstract_inverted_index.(SGLT2) | 10 |
| abstract_inverted_index.1:0.00, | 104 |
| abstract_inverted_index.1:0.01, | 105 |
| abstract_inverted_index.1:0.02, | 106 |
| abstract_inverted_index.1:0.04, | 107 |
| abstract_inverted_index.Fickian | 182 |
| abstract_inverted_index.between | 240 |
| abstract_inverted_index.binding | 225 |
| abstract_inverted_index.casting | 119 |
| abstract_inverted_index.dioxide | 74, 99, 196, 259 |
| abstract_inverted_index.kinetic | 141 |
| abstract_inverted_index.lowered | 216 |
| abstract_inverted_index.partial | 189 |
| abstract_inverted_index.present | 51 |
| abstract_inverted_index.reduced | 35 |
| abstract_inverted_index.release | 82, 126, 147, 199, 245 |
| abstract_inverted_index.silicon | 73, 98, 195, 210, 258 |
| abstract_inverted_index.solvent | 121 |
| abstract_inverted_index.studies | 127 |
| abstract_inverted_index.without | 202 |
| abstract_inverted_index.(namely, | 110 |
| abstract_inverted_index.Purpose: | 2 |
| abstract_inverted_index.Results: | 178 |
| abstract_inverted_index.Swelling | 123, 179 |
| abstract_inverted_index.activity | 62 |
| abstract_inverted_index.assessed | 169 |
| abstract_inverted_index.believed | 42 |
| abstract_inverted_index.diabetes | 19, 28, 278 |
| abstract_inverted_index.dynamics | 77 |
| abstract_inverted_index.followed | 181 |
| abstract_inverted_index.glaucoma | 24 |
| abstract_inverted_index.markers. | 49 |
| abstract_inverted_index.measured | 153 |
| abstract_inverted_index.mellitus | 29 |
| abstract_inverted_index.necrosis | 235 |
| abstract_inverted_index.patients | 30, 274 |
| abstract_inverted_index.pattern. | 208 |
| abstract_inverted_index.pressure | 59, 151, 218, 242, 266 |
| abstract_inverted_index.solution | 136 |
| abstract_inverted_index.studied. | 86 |
| abstract_inverted_index.swelling | 79, 144 |
| abstract_inverted_index.Approach: | 88 |
| abstract_inverted_index.Moreover, | 164 |
| abstract_inverted_index.behaviour | 180 |
| abstract_inverted_index.colloidal | 72 |
| abstract_inverted_index.conducted | 132 |
| abstract_inverted_index.different | 101 |
| abstract_inverted_index.diffusion | 207 |
| abstract_inverted_index.following | 205 |
| abstract_inverted_index.including | 97 |
| abstract_inverted_index.inhibitor | 11 |
| abstract_inverted_index.mechanism | 183 |
| abstract_inverted_index.mellitus. | 20, 279 |
| abstract_inverted_index.phosphate | 134 |
| abstract_inverted_index.prepared, | 96 |
| abstract_inverted_index.promising | 220 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.affinities | 226 |
| abstract_inverted_index.containing | 194, 255 |
| abstract_inverted_index.controlled | 271 |
| abstract_inverted_index.evaluated. | 149 |
| abstract_inverted_index.factor-α. | 236 |
| abstract_inverted_index.favourable | 224 |
| abstract_inverted_index.management | 15 |
| abstract_inverted_index.mechanisms | 142 |
| abstract_inverted_index.monitoring | 57 |
| abstract_inverted_index.relaxation | 190 |
| abstract_inverted_index.undertaken | 55 |
| abstract_inverted_index.Conclusion: | 249 |
| abstract_inverted_index.Interleukin | 231 |
| abstract_inverted_index.Intraocular | 150 |
| abstract_inverted_index.application | 155 |
| abstract_inverted_index.correlation | 239 |
| abstract_inverted_index.inhibitors. | 38 |
| abstract_inverted_index.intraocular | 58, 217, 241, 265 |
| abstract_inverted_index.performance | 83 |
| abstract_inverted_index.Experimental | 87 |
| abstract_inverted_index.established. | 248 |
| abstract_inverted_index.evaporation. | 122 |
| abstract_inverted_index.formulation. | 68 |
| abstract_inverted_index.inflammation | 175, 268 |
| abstract_inverted_index.inflammatory | 48 |
| abstract_inverted_index.normotensive | 161 |
| abstract_inverted_index.Empagliflozin | 3, 39 |
| abstract_inverted_index.Hydroxypropyl | 89 |
| abstract_inverted_index.cotransporter | 8 |
| abstract_inverted_index.empagliflozin | 65, 94, 256 |
| abstract_inverted_index.respectively) | 117 |
| abstract_inverted_index.significantly | 215 |
| abstract_inverted_index.dioxide-loaded | 211 |
| abstract_inverted_index.sodium-glucose | 7 |
| abstract_inverted_index.Interleukin-1β, | 230 |
| abstract_inverted_index.anti-inflammation | 222 |
| abstract_inverted_index.anti-inflammatory | 61, 166 |
| abstract_inverted_index.hydroxypropyl | 251 |
| abstract_inverted_index.carrageenan-induced | 174 |
| abstract_inverted_index.methylcellulose-based | 90, 252 |
| abstract_inverted_index.EMA3<EMA2<EMA0<EMA4<EMA1, | 187 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| citation_normalized_percentile |