Hypothalamic gliosis as a potential mediator of improved glucose tolerance induced by time-restricted feeding in obese mice Article Swipe
Camila Astudillo-Guerrero
,
Daniela Fernandois
,
Émilie Caron
,
Vincent Prévot
,
Joshua P. Thaler
,
Mauricio D. Dorfman
,
Gonzalo Cruz
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1152/ajpcell.00357.2025
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1152/ajpcell.00357.2025
This study shows that time-restricted feeding (TRF) improves glucose tolerance in obese mice independently of weight loss. Surprisingly, this benefit is linked to increased hypothalamic gliosis, challenging the view that gliosis is solely detrimental in obesity. Although TRF elevates circulating β-hydroxybutyrate (BHB), peripheral and central BHB delivery fails to mimic TRF’s glycemic benefits or affect hypothalamic gliosis. These findings suggest gliosis may play a previously unrecognized role in mediating TRF’s metabolic benefits.
Related Topics
Concepts
Gliosis
Endocrinology
Internal medicine
Inflammation
Diet-induced obese
Impaired glucose tolerance
Medicine
Glucose homeostasis
Obesity
Energy homeostasis
Glycemic
Biology
Diabetes mellitus
Insulin resistance
Pathology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1152/ajpcell.00357.2025
- OA Status
- hybrid
- References
- 53
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412786521
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4412786521Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1152/ajpcell.00357.2025Digital Object Identifier
- Title
-
Hypothalamic gliosis as a potential mediator of improved glucose tolerance induced by time-restricted feeding in obese miceWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
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2025-07-31Full publication date if available
- Authors
-
Camila Astudillo-Guerrero, Daniela Fernandois, Émilie Caron, Vincent Prévot, Joshua P. Thaler, Mauricio D. Dorfman, Gonzalo CruzList of authors in order
- Landing page
-
https://doi.org/10.1152/ajpcell.00357.2025Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1152/ajpcell.00357.2025Direct OA link when available
- Concepts
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Gliosis, Endocrinology, Internal medicine, Inflammation, Diet-induced obese, Impaired glucose tolerance, Medicine, Glucose homeostasis, Obesity, Energy homeostasis, Glycemic, Biology, Diabetes mellitus, Insulin resistance, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
53Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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