Hypothalamic Menin regulates systemic aging and cognitive decline Article Swipe
Lige Leng
,
Ziqi Yuan
,
Xiao Su
,
Zhenlei Chen
,
Shangchen Yang
,
Meiqin Chen
,
Kai Zhuang
,
Hui Lin
,
Hao Sun
,
Huifang Li
,
Maoqiang Xue
,
Jun Xu
,
Jingqi Yan
,
Zhenyi Chen
,
Ti‐Fei Yuan
,
Jie Zhang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pbio.3002033
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pbio.3002033
Aging is a systemic process, which is a risk factor for impaired physiological functions, and finally death. The molecular mechanisms driving aging process and the associated cognitive decline are not fully understood. The hypothalamus acts as the arbiter that orchestrates systemic aging through neuroinflammatory signaling. Our recent findings revealed that Menin plays important roles in neuroinflammation and brain development. Here, we found that the hypothalamic Menin signaling diminished in aged mice, which correlates with systemic aging and cognitive deficits. Restoring Menin expression in ventromedial nucleus of hypothalamus (VMH) of aged mice extended lifespan, improved learning and memory, and ameliorated aging biomarkers, while inhibiting Menin in VMH of middle-aged mice induced premature aging and accelerated cognitive decline. We further found that Menin epigenetically regulates neuroinflammatory and metabolic pathways, including D-serine metabolism. Aging-associated Menin reduction led to impaired D-serine release by VMH-hippocampus neural circuit, while D-serine supplement rescued cognitive decline in aged mice. Collectively, VMH Menin serves as a key regulator of systemic aging and aging-related cognitive decline.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pbio.3002033
- https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002033&type=printable
- OA Status
- gold
- Cited By
- 21
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4327568797
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https://openalex.org/W4327568797Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.pbio.3002033Digital Object Identifier
- Title
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Hypothalamic Menin regulates systemic aging and cognitive declineWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-03-16Full publication date if available
- Authors
-
Lige Leng, Ziqi Yuan, Xiao Su, Zhenlei Chen, Shangchen Yang, Meiqin Chen, Kai Zhuang, Hui Lin, Hao Sun, Huifang Li, Maoqiang Xue, Jun Xu, Jingqi Yan, Zhenyi Chen, Ti‐Fei Yuan, Jie ZhangList of authors in order
- Landing page
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https://doi.org/10.1371/journal.pbio.3002033Publisher landing page
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002033&type=printableDirect link to full text PDF
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002033&type=printableDirect OA link when available
- Concepts
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Cognitive decline, Neuroinflammation, Biology, Hippocampus, Neuroscience, Hypothalamus, Endocrinology, Cognition, Internal medicine, Dementia, Medicine, Inflammation, Immunology, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
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21Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6, 2024: 10, 2023: 5Per-year citation counts (last 5 years)
- References (count)
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43Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5028224510, https://openalex.org/A5100395265, https://openalex.org/A5059106502, https://openalex.org/A5041284688, https://openalex.org/A5109545438, https://openalex.org/A5101957040, https://openalex.org/A5108534246, https://openalex.org/A5008808439, https://openalex.org/A5027292853, https://openalex.org/A5023210873, https://openalex.org/A5084458701, https://openalex.org/A5006859498, https://openalex.org/A5050414405, https://openalex.org/A5100436845, https://openalex.org/A5061711797, https://openalex.org/A5029920666 |
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