Hypoxic mesenchymal stem cell secretome upregulates IL-10 and STAT3 gene expressions in mice model with polycystic ovary syndrome Article Swipe
Lusiana Lusiana
,
Dewi Masyithah Darlan
,
Setyo Trisnadi
,
Agung Putra
,
Nur Dina Amalina
,
Sofian Azalia Husain
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.52225/narrax.v2i3.176
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.52225/narrax.v2i3.176
Polycystic Ovary Syndrome (PCOS) is a condition characterized by chronic anovulation and hyperandrogenism, which often leads to infertility. It is closely associated with chronic inflammation triggered by glucose and saturated fat, contributing to hyperandrogenism and negatively impacting a patient’s quality of life. Effective therapeutic approaches are essential to address these issues. The secretome of Mesenchymal Stem Cells (MSCs) has demonstrated the ability to suppress pro-inflammatory cytokine secretion and regulate growth factors. The aim of this study was to investigate the effect of Hypoxic Mesenchymal Stem Cell Secretome (MHSSCs) on the expression of Interleukin-10 (IL-10) and Signal Transducer and Activator of Transcription 3 (STAT3) genes in a PCOS-induced mouse model. An in vivo experimental study was conducted using a post-test-only control group design. A total of 24 female C57BL/6 mice were divided into four groups: healthy control, negative control (PCOS mice injected with 0.9% NaCl), T1 (PCOS mice administered 200 μL of MHSSCs), and T2 (PCOS mice administered 400 μL of MHSSCs) for 33 days. Gene expression levels of IL-10 and STAT3 were quantified using quantitative reverse transcription polymerase chain reaction (qRT-PCR), normalized to the expression of the housekeeping gene β-actin. Statistical analysis using One-Way ANOVA followed by the LSD post hoc test was then performed. The results showed a significant increase in IL-10 expression in the T2 group compared to the negative control group (p<0.001). STAT3 expression was significantly higher in the T2 group compared to the negative control group (p=0.035). A dose-dependent effect was observed, with the T2 group demonstrating the highest upregulation of both IL-10 and STAT3 expression levels. In conclusion, the administration of MHSSCs effectively increased IL-10 and STAT3 gene expression, suggesting their potential as a therapeutic strategy to alleviate inflammation in PCOS.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.52225/narrax.v2i3.176
- https://narrax.org/main/article/download/176/110
- OA Status
- hybrid
- Cited By
- 1
- References
- 21
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4405940548Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.52225/narrax.v2i3.176Digital Object Identifier
- Title
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Hypoxic mesenchymal stem cell secretome upregulates IL-10 and STAT3 gene expressions in mice model with polycystic ovary syndromeWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-12-31Full publication date if available
- Authors
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Lusiana Lusiana, Dewi Masyithah Darlan, Setyo Trisnadi, Agung Putra, Nur Dina Amalina, Sofian Azalia HusainList of authors in order
- Landing page
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https://doi.org/10.52225/narrax.v2i3.176Publisher landing page
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https://narrax.org/main/article/download/176/110Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://narrax.org/main/article/download/176/110Direct OA link when available
- Concepts
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Mesenchymal stem cell, Polycystic ovary, Ovary, Gene, Biology, Andrology, Cell biology, Endocrinology, Medicine, Genetics, Insulin, Insulin resistanceTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.33 | 162 |
| abstract_inverted_index.An | 109 |
| abstract_inverted_index.In | 261 |
| abstract_inverted_index.It | 18 |
| abstract_inverted_index.T1 | 144 |
| abstract_inverted_index.T2 | 153, 216, 232, 248 |
| abstract_inverted_index.as | 277 |
| abstract_inverted_index.by | 8, 26, 196 |
| abstract_inverted_index.in | 104, 110, 211, 214, 230, 284 |
| abstract_inverted_index.is | 4, 19 |
| abstract_inverted_index.of | 40, 53, 73, 81, 91, 99, 124, 150, 159, 167, 185, 254, 265 |
| abstract_inverted_index.on | 88 |
| abstract_inverted_index.to | 16, 32, 47, 62, 77, 182, 219, 235, 281 |
| abstract_inverted_index.200 | 148 |
| abstract_inverted_index.400 | 157 |
| abstract_inverted_index.LSD | 198 |
| abstract_inverted_index.The | 51, 71, 205 |
| abstract_inverted_index.aim | 72 |
| abstract_inverted_index.and | 11, 28, 34, 67, 94, 97, 152, 169, 257, 270 |
| abstract_inverted_index.are | 45 |
| abstract_inverted_index.for | 161 |
| abstract_inverted_index.has | 58 |
| abstract_inverted_index.hoc | 200 |
| abstract_inverted_index.the | 60, 79, 89, 183, 186, 197, 215, 220, 231, 236, 247, 251, 263 |
| abstract_inverted_index.was | 76, 114, 202, 227, 244 |
| abstract_inverted_index.μL | 149, 158 |
| abstract_inverted_index.0.9% | 142 |
| abstract_inverted_index.Cell | 85 |
| abstract_inverted_index.Gene | 164 |
| abstract_inverted_index.Stem | 55, 84 |
| abstract_inverted_index.both | 255 |
| abstract_inverted_index.fat, | 30 |
| abstract_inverted_index.four | 132 |
| abstract_inverted_index.gene | 188, 272 |
| abstract_inverted_index.into | 131 |
| abstract_inverted_index.mice | 128, 139, 146, 155 |
| abstract_inverted_index.post | 199 |
| abstract_inverted_index.test | 201 |
| abstract_inverted_index.then | 203 |
| abstract_inverted_index.this | 74 |
| abstract_inverted_index.vivo | 111 |
| abstract_inverted_index.were | 129, 171 |
| abstract_inverted_index.with | 22, 141, 246 |
| abstract_inverted_index.(PCOS | 138, 145, 154 |
| abstract_inverted_index.ANOVA | 194 |
| abstract_inverted_index.Cells | 56 |
| abstract_inverted_index.IL-10 | 168, 212, 256, 269 |
| abstract_inverted_index.Ovary | 1 |
| abstract_inverted_index.PCOS. | 285 |
| abstract_inverted_index.STAT3 | 170, 225, 258, 271 |
| abstract_inverted_index.chain | 178 |
| abstract_inverted_index.days. | 163 |
| abstract_inverted_index.genes | 103 |
| abstract_inverted_index.group | 120, 217, 223, 233, 239, 249 |
| abstract_inverted_index.leads | 15 |
| abstract_inverted_index.life. | 41 |
| abstract_inverted_index.mouse | 107 |
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| abstract_inverted_index.study | 75, 113 |
| abstract_inverted_index.their | 275 |
| abstract_inverted_index.these | 49 |
| abstract_inverted_index.total | 123 |
| abstract_inverted_index.using | 116, 173, 192 |
| abstract_inverted_index.which | 13 |
| abstract_inverted_index.(MSCs) | 57 |
| abstract_inverted_index.(PCOS) | 3 |
| abstract_inverted_index.MHSSCs | 266 |
| abstract_inverted_index.NaCl), | 143 |
| abstract_inverted_index.Signal | 95 |
| abstract_inverted_index.effect | 80, 243 |
| abstract_inverted_index.female | 126 |
| abstract_inverted_index.growth | 69 |
| abstract_inverted_index.higher | 229 |
| abstract_inverted_index.levels | 166 |
| abstract_inverted_index.model. | 108 |
| abstract_inverted_index.showed | 207 |
| abstract_inverted_index.(IL-10) | 93 |
| abstract_inverted_index.(STAT3) | 102 |
| abstract_inverted_index.C57BL/6 | 127 |
| abstract_inverted_index.Hypoxic | 82 |
| abstract_inverted_index.MHSSCs) | 160 |
| abstract_inverted_index.One-Way | 193 |
| abstract_inverted_index.ability | 61 |
| abstract_inverted_index.address | 48 |
| abstract_inverted_index.chronic | 9, 23 |
| abstract_inverted_index.closely | 20 |
| abstract_inverted_index.control | 119, 137, 222, 238 |
| abstract_inverted_index.design. | 121 |
| abstract_inverted_index.divided | 130 |
| abstract_inverted_index.glucose | 27 |
| abstract_inverted_index.groups: | 133 |
| abstract_inverted_index.healthy | 134 |
| abstract_inverted_index.highest | 252 |
| abstract_inverted_index.issues. | 50 |
| abstract_inverted_index.levels. | 260 |
| abstract_inverted_index.quality | 39 |
| abstract_inverted_index.results | 206 |
| abstract_inverted_index.reverse | 175 |
| abstract_inverted_index.(MHSSCs) | 87 |
| abstract_inverted_index.MHSSCs), | 151 |
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| abstract_inverted_index.analysis | 191 |
| abstract_inverted_index.compared | 218, 234 |
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| abstract_inverted_index.cytokine | 65 |
| abstract_inverted_index.factors. | 70 |
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| abstract_inverted_index.injected | 140 |
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| abstract_inverted_index.strategy | 280 |
| abstract_inverted_index.suppress | 63 |
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| abstract_inverted_index.Effective | 42 |
| abstract_inverted_index.Secretome | 86 |
| abstract_inverted_index.alleviate | 282 |
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| abstract_inverted_index.conducted | 115 |
| abstract_inverted_index.essential | 46 |
| abstract_inverted_index.impacting | 36 |
| abstract_inverted_index.increased | 268 |
| abstract_inverted_index.observed, | 245 |
| abstract_inverted_index.potential | 276 |
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| abstract_inverted_index.secretion | 66 |
| abstract_inverted_index.secretome | 52 |
| abstract_inverted_index.triggered | 25 |
| abstract_inverted_index.β-actin. | 189 |
| abstract_inverted_index.(p=0.035). | 240 |
| abstract_inverted_index.(qRT-PCR), | 180 |
| abstract_inverted_index.Polycystic | 0 |
| abstract_inverted_index.Transducer | 96 |
| abstract_inverted_index.approaches | 44 |
| abstract_inverted_index.associated | 21 |
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| abstract_inverted_index.negatively | 35 |
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| abstract_inverted_index.polymerase | 177 |
| abstract_inverted_index.quantified | 172 |
| abstract_inverted_index.suggesting | 274 |
| abstract_inverted_index.Mesenchymal | 54, 83 |
| abstract_inverted_index.Statistical | 190 |
| abstract_inverted_index.anovulation | 10 |
| abstract_inverted_index.conclusion, | 262 |
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| abstract_inverted_index.expression, | 273 |
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| abstract_inverted_index.patient’s | 38 |
| abstract_inverted_index.significant | 209 |
| abstract_inverted_index.therapeutic | 43, 279 |
| abstract_inverted_index.PCOS-induced | 106 |
| abstract_inverted_index.administered | 147, 156 |
| abstract_inverted_index.contributing | 31 |
| abstract_inverted_index.demonstrated | 59 |
| abstract_inverted_index.experimental | 112 |
| abstract_inverted_index.housekeeping | 187 |
| abstract_inverted_index.infertility. | 17 |
| abstract_inverted_index.inflammation | 24, 283 |
| abstract_inverted_index.quantitative | 174 |
| abstract_inverted_index.upregulation | 253 |
| abstract_inverted_index.(p<0.001). | 224 |
| abstract_inverted_index.Transcription | 100 |
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| abstract_inverted_index.demonstrating | 250 |
| abstract_inverted_index.significantly | 228 |
| abstract_inverted_index.transcription | 176 |
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| abstract_inverted_index.administration | 264 |
| abstract_inverted_index.dose-dependent | 242 |
| abstract_inverted_index.post-test-only | 118 |
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| abstract_inverted_index.pro-inflammatory | 64 |
| abstract_inverted_index.hyperandrogenism, | 12 |
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| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7099999785423279 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.75873081 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |