N -Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad-Spectrum Antialphaviral Activity Article Swipe
Anirban Ghoshal
,
John D. Sears
,
Mohammad Anwar Hossain
,
Edwin G. Tse
,
Stefanie Howell
,
Jane Burdick
,
Noah L. Morales
,
Sabian A. Martinez
,
Isabella Law
,
Zachary J. Streblow
,
Daniel N. Streblow
,
Rafael M. Couñago
,
Nathaniel J. Moorman
,
Mark T. Heise
,
Timothy M. Willson
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acs.jmedchem.5c01802
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acs.jmedchem.5c01802
The emergence of mosquito-borne alphaviruses that cause chronic arthritis or encephalitis underscores the urgent need for broad-spectrum antiviral therapeutics. The viral nsP2 cysteine protease, which is essential for alphavirus replication, is a promising antiviral target. Vinyl sulfone covalent inhibitors potently inhibit nsP2 protease but suffer from glutathione reactivity and species-dependent systemic clearance catalyzed by glutathione S-transferase. To address these liabilities, we explored alternative electrophilic warheads and identified acetamide inhibitors bearing N-alkyl sulfamate warheads with improved biochemical and antiviral profiles. 2-((5-(2-Ethoxyphenyl)-1H-pyrazol-3-yl)amino)-2-oxoethyl methylsulfamate emerged as a lead compound with potency against New and Old World alphaviruses, low GSH reactivity, and proteome-wide selectivity. Despite its promising antialphaviral activity, 2-((5-(2-ethoxyphenyl)-1H-pyrazol-3-yl)amino)-2-oxoethyl methylsulfamate exhibited rapid clearance due to hepatic glucuronidation. Structure-activity studies revealed modifications that improve metabolic stability while retaining antiviral activity. These findings introduce sulfamate acetamides as a new class of covalent nsP2 protease inhibitors and direct-acting pan-alphavirus drugs.
Related Topics
Concepts
No concepts available.
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acs.jmedchem.5c01802
- OA Status
- green
- Cited By
- 1
- References
- 38
- OpenAlex ID
- https://openalex.org/W4415207184
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4415207184Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1021/acs.jmedchem.5c01802Digital Object Identifier
- Title
-
N -Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad-Spectrum Antialphaviral ActivityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-10-15Full publication date if available
- Authors
-
Anirban Ghoshal, John D. Sears, Mohammad Anwar Hossain, Edwin G. Tse, Stefanie Howell, Jane Burdick, Noah L. Morales, Sabian A. Martinez, Isabella Law, Zachary J. Streblow, Daniel N. Streblow, Rafael M. Couñago, Nathaniel J. Moorman, Mark T. Heise, Timothy M. WillsonList of authors in order
- Landing page
-
https://doi.org/10.1021/acs.jmedchem.5c01802Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/12621199Direct OA link when available
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
38Number of works referenced by this work
Full payload
| id | https://openalex.org/W4415207184 |
|---|---|
| doi | https://doi.org/10.1021/acs.jmedchem.5c01802 |
| ids.doi | https://doi.org/10.1021/acs.jmedchem.5c01802 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/41090377 |
| ids.openalex | https://openalex.org/W4415207184 |
| fwci | 4.40320365 |
| mesh[0].qualifier_ui | Q000494 |
| mesh[0].descriptor_ui | D000998 |
| mesh[0].is_major_topic | True |
| mesh[0].qualifier_name | pharmacology |
| mesh[0].descriptor_name | Antiviral Agents |
| mesh[1].qualifier_ui | Q000737 |
| mesh[1].descriptor_ui | D000998 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | chemistry |
| mesh[1].descriptor_name | Antiviral Agents |
| mesh[2].qualifier_ui | Q000138 |
| mesh[2].descriptor_ui | D000998 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | chemical synthesis |
| mesh[2].descriptor_name | Antiviral Agents |
| mesh[3].qualifier_ui | Q000494 |
| mesh[3].descriptor_ui | D013451 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | pharmacology |
| mesh[3].descriptor_name | Sulfonic Acids |
| mesh[4].qualifier_ui | Q000737 |
| mesh[4].descriptor_ui | D013451 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | chemistry |
| mesh[4].descriptor_name | Sulfonic Acids |
| mesh[5].qualifier_ui | Q000138 |
| mesh[5].descriptor_ui | D013451 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | chemical synthesis |
| mesh[5].descriptor_name | Sulfonic Acids |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D000818 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Animals |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D013329 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Structure-Activity Relationship |
| mesh[8].qualifier_ui | Q000494 |
| mesh[8].descriptor_ui | D015853 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | pharmacology |
| mesh[8].descriptor_name | Cysteine Proteinase Inhibitors |
| mesh[9].qualifier_ui | Q000737 |
| mesh[9].descriptor_ui | D015853 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | chemistry |
| mesh[9].descriptor_name | Cysteine Proteinase Inhibitors |
| mesh[10].qualifier_ui | Q000138 |
| mesh[10].descriptor_ui | D015853 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | chemical synthesis |
| mesh[10].descriptor_name | Cysteine Proteinase Inhibitors |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D006801 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Humans |
| mesh[12].qualifier_ui | Q000187 |
| mesh[12].descriptor_ui | D000524 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | drug effects |
| mesh[12].descriptor_name | Alphavirus |
| mesh[13].qualifier_ui | Q000201 |
| mesh[13].descriptor_ui | D000524 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | enzymology |
| mesh[13].descriptor_name | Alphavirus |
| mesh[14].qualifier_ui | Q000037 |
| mesh[14].descriptor_ui | D017361 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | antagonists & inhibitors |
| mesh[14].descriptor_name | Viral Nonstructural Proteins |
| mesh[15].qualifier_ui | Q000494 |
| mesh[15].descriptor_ui | D000998 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | pharmacology |
| mesh[15].descriptor_name | Antiviral Agents |
| mesh[16].qualifier_ui | Q000737 |
| mesh[16].descriptor_ui | D000998 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | chemistry |
| mesh[16].descriptor_name | Antiviral Agents |
| mesh[17].qualifier_ui | Q000138 |
| mesh[17].descriptor_ui | D000998 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | chemical synthesis |
| mesh[17].descriptor_name | Antiviral Agents |
| mesh[18].qualifier_ui | Q000494 |
| mesh[18].descriptor_ui | D013451 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | pharmacology |
| mesh[18].descriptor_name | Sulfonic Acids |
| mesh[19].qualifier_ui | Q000737 |
| mesh[19].descriptor_ui | D013451 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | chemistry |
| mesh[19].descriptor_name | Sulfonic Acids |
| mesh[20].qualifier_ui | Q000138 |
| mesh[20].descriptor_ui | D013451 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | chemical synthesis |
| mesh[20].descriptor_name | Sulfonic Acids |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D000818 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Animals |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D013329 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Structure-Activity Relationship |
| mesh[23].qualifier_ui | Q000494 |
| mesh[23].descriptor_ui | D015853 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | pharmacology |
| mesh[23].descriptor_name | Cysteine Proteinase Inhibitors |
| mesh[24].qualifier_ui | Q000737 |
| mesh[24].descriptor_ui | D015853 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | chemistry |
| mesh[24].descriptor_name | Cysteine Proteinase Inhibitors |
| mesh[25].qualifier_ui | Q000138 |
| mesh[25].descriptor_ui | D015853 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | chemical synthesis |
| mesh[25].descriptor_name | Cysteine Proteinase Inhibitors |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D006801 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Humans |
| mesh[27].qualifier_ui | Q000187 |
| mesh[27].descriptor_ui | D000524 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | drug effects |
| mesh[27].descriptor_name | Alphavirus |
| mesh[28].qualifier_ui | Q000201 |
| mesh[28].descriptor_ui | D000524 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | enzymology |
| mesh[28].descriptor_name | Alphavirus |
| mesh[29].qualifier_ui | Q000037 |
| mesh[29].descriptor_ui | D017361 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | antagonists & inhibitors |
| mesh[29].descriptor_name | Viral Nonstructural Proteins |
| type | article |
| title | N -Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad-Spectrum Antialphaviral Activity |
| biblio.issue | 21 |
| biblio.volume | 68 |
| biblio.last_page | 22937 |
| biblio.first_page | 22918 |
| topics[0].id | https://openalex.org/T10526 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9994000196456909 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2725 |
| topics[0].subfield.display_name | Infectious Diseases |
| topics[0].display_name | HIV/AIDS drug development and treatment |
| topics[1].id | https://openalex.org/T12827 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9991999864578247 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Biochemical and Molecular Research |
| topics[2].id | https://openalex.org/T10823 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9980999827384949 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2739 |
| topics[2].subfield.display_name | Public Health, Environmental and Occupational Health |
| topics[2].display_name | Research on Leishmaniasis Studies |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| language | en |
| locations[0].id | doi:10.1021/acs.jmedchem.5c01802 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S162030435 |
| locations[0].source.issn | 0022-2623, 1520-4804 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0022-2623 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Journal of Medicinal Chemistry |
| locations[0].source.host_organization | https://openalex.org/P4310320006 |
| locations[0].source.host_organization_name | American Chemical Society |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320006 |
| locations[0].source.host_organization_lineage_names | American Chemical Society |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Medicinal Chemistry |
| locations[0].landing_page_url | https://doi.org/10.1021/acs.jmedchem.5c01802 |
| locations[1].id | pmid:41090377 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of medicinal chemistry |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/41090377 |
| locations[2].id | pmh:oai:europepmc.org:11429547 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | cc-by-nc-nd |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12621199 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5023080172 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-9359-6074 |
| authorships[0].author.display_name | Anirban Ghoshal |
| authorships[0].countries | CA, US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[0].affiliations[0].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[0].affiliations[1].raw_affiliation_string | READDI AViDD Center |
| authorships[0].affiliations[2].institution_ids | https://openalex.org/I2803004491 |
| authorships[0].affiliations[2].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[0].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[0].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[0].institutions[0].type | nonprofit |
| authorships[0].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[0].institutions[0].country_code | CA |
| authorships[0].institutions[0].display_name | Structural Genomics Consortium |
| authorships[0].institutions[1].id | https://openalex.org/I114027177 |
| authorships[0].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[0].institutions[1].country_code | US |
| authorships[0].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Anirban Ghoshal |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | READDI AViDD Center, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[1].author.id | https://openalex.org/A5016529302 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-4713-2241 |
| authorships[1].author.display_name | John D. Sears |
| authorships[1].countries | US |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Microbiology and Immunology |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I114027177 |
| authorships[1].affiliations[1].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[1].institutions[0].id | https://openalex.org/I114027177 |
| authorships[1].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | John D. Sears |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Microbiology and Immunology, University of North Carolina at Chapel Hill |
| authorships[2].author.id | https://openalex.org/A5084841942 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-8684-8755 |
| authorships[2].author.display_name | Mohammad Anwar Hossain |
| authorships[2].countries | CA, US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[2].affiliations[0].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[2].affiliations[1].raw_affiliation_string | READDI AViDD Center |
| authorships[2].affiliations[2].institution_ids | https://openalex.org/I2803004491 |
| authorships[2].affiliations[2].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[2].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[2].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[2].institutions[0].type | nonprofit |
| authorships[2].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[2].institutions[0].country_code | CA |
| authorships[2].institutions[0].display_name | Structural Genomics Consortium |
| authorships[2].institutions[1].id | https://openalex.org/I114027177 |
| authorships[2].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[2].institutions[1].country_code | US |
| authorships[2].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Mohammad Anwar Hossain |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | READDI AViDD Center, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[3].author.id | https://openalex.org/A5086780199 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-9133-9274 |
| authorships[3].author.display_name | Edwin G. Tse |
| authorships[3].countries | CA, US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2803004491 |
| authorships[3].affiliations[0].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I114027177 |
| authorships[3].affiliations[1].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[3].affiliations[2].raw_affiliation_string | READDI AViDD Center |
| authorships[3].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[3].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[3].institutions[0].type | nonprofit |
| authorships[3].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[3].institutions[0].country_code | CA |
| authorships[3].institutions[0].display_name | Structural Genomics Consortium |
| authorships[3].institutions[1].id | https://openalex.org/I114027177 |
| authorships[3].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[3].institutions[1].country_code | US |
| authorships[3].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Edwin G. Tse |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | READDI AViDD Center, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[4].author.id | https://openalex.org/A5073799816 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-2039-9245 |
| authorships[4].author.display_name | Stefanie Howell |
| authorships[4].countries | CA, US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I2803004491 |
| authorships[4].affiliations[0].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[4].affiliations[1].raw_affiliation_string | READDI AViDD Center |
| authorships[4].affiliations[2].institution_ids | https://openalex.org/I114027177 |
| authorships[4].affiliations[2].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[4].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[4].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[4].institutions[0].type | nonprofit |
| authorships[4].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[4].institutions[0].country_code | CA |
| authorships[4].institutions[0].display_name | Structural Genomics Consortium |
| authorships[4].institutions[1].id | https://openalex.org/I114027177 |
| authorships[4].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[4].institutions[1].country_code | US |
| authorships[4].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Stefanie Howell |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | READDI AViDD Center, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[5].author.id | https://openalex.org/A5102723378 |
| authorships[5].author.orcid | https://orcid.org/0009-0001-9719-8302 |
| authorships[5].author.display_name | Jane Burdick |
| authorships[5].countries | US |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Genetics |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I114027177 |
| authorships[5].affiliations[1].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[5].institutions[0].id | https://openalex.org/I114027177 |
| authorships[5].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Jane E. Burdick |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Genetics, University of North Carolina at Chapel Hill |
| authorships[6].author.id | https://openalex.org/A5104336008 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Noah L. Morales |
| authorships[6].countries | US |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Genetics |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I114027177 |
| authorships[6].affiliations[1].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[6].institutions[0].id | https://openalex.org/I114027177 |
| authorships[6].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Noah L. Morales |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Genetics, University of North Carolina at Chapel Hill |
| authorships[7].author.id | https://openalex.org/A5035122429 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-1333-5083 |
| authorships[7].author.display_name | Sabian A. Martinez |
| authorships[7].countries | US |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Genetics |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I114027177 |
| authorships[7].affiliations[1].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[7].institutions[0].id | https://openalex.org/I114027177 |
| authorships[7].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Sabian A. Martinez |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Genetics, University of North Carolina at Chapel Hill |
| authorships[8].author.id | https://openalex.org/A5047880729 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Isabella Law |
| authorships[8].countries | US |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Genetics |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I114027177 |
| authorships[8].affiliations[1].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[8].institutions[0].id | https://openalex.org/I114027177 |
| authorships[8].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Isabella Law |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Genetics, University of North Carolina at Chapel Hill |
| authorships[9].author.id | https://openalex.org/A5018885317 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Zachary J. Streblow |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I165690674 |
| authorships[9].affiliations[0].raw_affiliation_string | Oregon Health & Science University |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I114027177 |
| authorships[9].affiliations[1].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[9].affiliations[2].raw_affiliation_string | Vaccine & Gene Therapy Institute |
| authorships[9].institutions[0].id | https://openalex.org/I165690674 |
| authorships[9].institutions[0].ror | https://ror.org/009avj582 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I165690674 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | Oregon Health & Science University |
| authorships[9].institutions[1].id | https://openalex.org/I114027177 |
| authorships[9].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[9].institutions[1].type | education |
| authorships[9].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[9].institutions[1].country_code | US |
| authorships[9].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Zachary J. Streblow |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Oregon Health & Science University, University of North Carolina at Chapel Hill, Vaccine & Gene Therapy Institute |
| authorships[10].author.id | https://openalex.org/A5012696027 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-6828-2492 |
| authorships[10].author.display_name | Daniel N. Streblow |
| authorships[10].countries | US |
| authorships[10].affiliations[0].raw_affiliation_string | Vaccine & Gene Therapy Institute |
| authorships[10].affiliations[1].institution_ids | https://openalex.org/I165690674 |
| authorships[10].affiliations[1].raw_affiliation_string | Oregon Health & Science University |
| authorships[10].affiliations[2].institution_ids | https://openalex.org/I114027177 |
| authorships[10].affiliations[2].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[10].institutions[0].id | https://openalex.org/I165690674 |
| authorships[10].institutions[0].ror | https://ror.org/009avj582 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I165690674 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | Oregon Health & Science University |
| authorships[10].institutions[1].id | https://openalex.org/I114027177 |
| authorships[10].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[10].institutions[1].type | education |
| authorships[10].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[10].institutions[1].country_code | US |
| authorships[10].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Daniel N. Streblow |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Oregon Health & Science University, University of North Carolina at Chapel Hill, Vaccine & Gene Therapy Institute |
| authorships[11].author.id | https://openalex.org/A5058279045 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-1847-5090 |
| authorships[11].author.display_name | Rafael M. Couñago |
| authorships[11].countries | CA, US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[11].affiliations[0].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[11].affiliations[1].raw_affiliation_string | READDI AViDD Center |
| authorships[11].affiliations[2].institution_ids | https://openalex.org/I2803004491 |
| authorships[11].affiliations[2].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[11].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[11].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[11].institutions[0].type | nonprofit |
| authorships[11].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[11].institutions[0].country_code | CA |
| authorships[11].institutions[0].display_name | Structural Genomics Consortium |
| authorships[11].institutions[1].id | https://openalex.org/I114027177 |
| authorships[11].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[11].institutions[1].type | education |
| authorships[11].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[11].institutions[1].country_code | US |
| authorships[11].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Rafael M. Couñago |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | READDI AViDD Center, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| authorships[12].author.id | https://openalex.org/A5116569758 |
| authorships[12].author.orcid | https://orcid.org/0009-0008-6391-3268 |
| authorships[12].author.display_name | Nathaniel J. Moorman |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[12].affiliations[0].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[12].affiliations[1].raw_affiliation_string | Department of Microbiology and Immunology |
| authorships[12].affiliations[2].raw_affiliation_string | READDI AViDD Center |
| authorships[12].institutions[0].id | https://openalex.org/I114027177 |
| authorships[12].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Nathaniel J. Moorman |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Department of Microbiology and Immunology, READDI AViDD Center, University of North Carolina at Chapel Hill |
| authorships[13].author.id | https://openalex.org/A5018924367 |
| authorships[13].author.orcid | https://orcid.org/0000-0001-5829-8477 |
| authorships[13].author.display_name | Mark T. Heise |
| authorships[13].countries | US |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Genetics |
| authorships[13].affiliations[1].institution_ids | https://openalex.org/I114027177 |
| authorships[13].affiliations[1].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[13].institutions[0].id | https://openalex.org/I114027177 |
| authorships[13].institutions[0].ror | https://ror.org/0130frc33 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I114027177 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | University of North Carolina at Chapel Hill |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Mark T. Heise |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Genetics, University of North Carolina at Chapel Hill |
| authorships[14].author.id | https://openalex.org/A5081551458 |
| authorships[14].author.orcid | https://orcid.org/0000-0003-4181-8223 |
| authorships[14].author.display_name | Timothy M. Willson |
| authorships[14].countries | CA, US |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I114027177 |
| authorships[14].affiliations[0].raw_affiliation_string | University of North Carolina at Chapel Hill |
| authorships[14].affiliations[1].institution_ids | https://openalex.org/I2803004491 |
| authorships[14].affiliations[1].raw_affiliation_string | Structural Genomics Consortium, UNC Eshelman School of Pharmacy |
| authorships[14].affiliations[2].raw_affiliation_string | READDI AViDD Center |
| authorships[14].institutions[0].id | https://openalex.org/I2803004491 |
| authorships[14].institutions[0].ror | https://ror.org/04jzps455 |
| authorships[14].institutions[0].type | nonprofit |
| authorships[14].institutions[0].lineage | https://openalex.org/I2803004491 |
| authorships[14].institutions[0].country_code | CA |
| authorships[14].institutions[0].display_name | Structural Genomics Consortium |
| authorships[14].institutions[1].id | https://openalex.org/I114027177 |
| authorships[14].institutions[1].ror | https://ror.org/0130frc33 |
| authorships[14].institutions[1].type | education |
| authorships[14].institutions[1].lineage | https://openalex.org/I114027177 |
| authorships[14].institutions[1].country_code | US |
| authorships[14].institutions[1].display_name | University of North Carolina at Chapel Hill |
| authorships[14].author_position | last |
| authorships[14].raw_author_name | Timothy M. Willson |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | READDI AViDD Center, Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12621199 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-16T00:00:00 |
| display_name | N -Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad-Spectrum Antialphaviral Activity |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-14T23:14:49.485078 |
| primary_topic.id | https://openalex.org/T10526 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9994000196456909 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2725 |
| primary_topic.subfield.display_name | Infectious Diseases |
| primary_topic.display_name | HIV/AIDS drug development and treatment |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | pmh:oai:europepmc.org:11429547 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306400806 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Europe PMC (PubMed Central) |
| best_oa_location.source.host_organization | https://openalex.org/I1303153112 |
| best_oa_location.source.host_organization_name | European Bioinformatics Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1303153112 |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12621199 |
| primary_location.id | doi:10.1021/acs.jmedchem.5c01802 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S162030435 |
| primary_location.source.issn | 0022-2623, 1520-4804 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0022-2623 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal of Medicinal Chemistry |
| primary_location.source.host_organization | https://openalex.org/P4310320006 |
| primary_location.source.host_organization_name | American Chemical Society |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320006 |
| primary_location.source.host_organization_lineage_names | American Chemical Society |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Medicinal Chemistry |
| primary_location.landing_page_url | https://doi.org/10.1021/acs.jmedchem.5c01802 |
| publication_date | 2025-10-15 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W3046627571, https://openalex.org/W4390684452, https://openalex.org/W2091846970, https://openalex.org/W3027525772, https://openalex.org/W2073517039, https://openalex.org/W4379964767, https://openalex.org/W4408343323, https://openalex.org/W4400592138, https://openalex.org/W1984075743, https://openalex.org/W4383262397, https://openalex.org/W4408309042, https://openalex.org/W4403298165, https://openalex.org/W4402266268, https://openalex.org/W4400130384, https://openalex.org/W4402036235, https://openalex.org/W4410309472, https://openalex.org/W4396704910, https://openalex.org/W4408074144, https://openalex.org/W2765393897, https://openalex.org/W4320481214, https://openalex.org/W4411084488, https://openalex.org/W4382894102, https://openalex.org/W4319165007, https://openalex.org/W2769901316, https://openalex.org/W2015811644, https://openalex.org/W2080595277, https://openalex.org/W2233988160, https://openalex.org/W2308578576, https://openalex.org/W2043875683, https://openalex.org/W4387492877, https://openalex.org/W2592471774, https://openalex.org/W2806985340, https://openalex.org/W2743704345, https://openalex.org/W2154179549, https://openalex.org/W2151349499, https://openalex.org/W2015694419, https://openalex.org/W2951532235, https://openalex.org/W2915847557 |
| referenced_works_count | 38 |
| abstract_inverted_index.a | 31, 83, 132 |
| abstract_inverted_index.To | 56 |
| abstract_inverted_index.as | 82, 131 |
| abstract_inverted_index.by | 53 |
| abstract_inverted_index.is | 25, 30 |
| abstract_inverted_index.of | 2, 135 |
| abstract_inverted_index.or | 9 |
| abstract_inverted_index.to | 111 |
| abstract_inverted_index.we | 60 |
| abstract_inverted_index.GSH | 95 |
| abstract_inverted_index.New | 89 |
| abstract_inverted_index.Old | 91 |
| abstract_inverted_index.The | 0, 19 |
| abstract_inverted_index.and | 48, 65, 76, 90, 97, 140 |
| abstract_inverted_index.but | 43 |
| abstract_inverted_index.due | 110 |
| abstract_inverted_index.for | 15, 27 |
| abstract_inverted_index.its | 101 |
| abstract_inverted_index.low | 94 |
| abstract_inverted_index.new | 133 |
| abstract_inverted_index.the | 12 |
| abstract_inverted_index.from | 45 |
| abstract_inverted_index.lead | 84 |
| abstract_inverted_index.need | 14 |
| abstract_inverted_index.nsP2 | 21, 41, 137 |
| abstract_inverted_index.that | 5, 118 |
| abstract_inverted_index.with | 73, 86 |
| abstract_inverted_index.These | 126 |
| abstract_inverted_index.Vinyl | 35 |
| abstract_inverted_index.World | 92 |
| abstract_inverted_index.cause | 6 |
| abstract_inverted_index.class | 134 |
| abstract_inverted_index.rapid | 108 |
| abstract_inverted_index.these | 58 |
| abstract_inverted_index.viral | 20 |
| abstract_inverted_index.which | 24 |
| abstract_inverted_index.while | 122 |
| abstract_inverted_index.drugs. | 143 |
| abstract_inverted_index.suffer | 44 |
| abstract_inverted_index.urgent | 13 |
| abstract_inverted_index.Despite | 100 |
| abstract_inverted_index.address | 57 |
| abstract_inverted_index.against | 88 |
| abstract_inverted_index.bearing | 69 |
| abstract_inverted_index.chronic | 7 |
| abstract_inverted_index.emerged | 81 |
| abstract_inverted_index.hepatic | 112 |
| abstract_inverted_index.improve | 119 |
| abstract_inverted_index.inhibit | 40 |
| abstract_inverted_index.potency | 87 |
| abstract_inverted_index.studies | 115 |
| abstract_inverted_index.sulfone | 36 |
| abstract_inverted_index.target. | 34 |
| abstract_inverted_index.compound | 85 |
| abstract_inverted_index.covalent | 37, 136 |
| abstract_inverted_index.cysteine | 22 |
| abstract_inverted_index.explored | 61 |
| abstract_inverted_index.findings | 127 |
| abstract_inverted_index.improved | 74 |
| abstract_inverted_index.potently | 39 |
| abstract_inverted_index.protease | 42, 138 |
| abstract_inverted_index.revealed | 116 |
| abstract_inverted_index.systemic | 50 |
| abstract_inverted_index.warheads | 64, 72 |
| abstract_inverted_index.acetamide | 67 |
| abstract_inverted_index.activity, | 104 |
| abstract_inverted_index.activity. | 125 |
| abstract_inverted_index.antiviral | 17, 33, 77, 124 |
| abstract_inverted_index.arthritis | 8 |
| abstract_inverted_index.catalyzed | 52 |
| abstract_inverted_index.clearance | 51, 109 |
| abstract_inverted_index.emergence | 1 |
| abstract_inverted_index.essential | 26 |
| abstract_inverted_index.exhibited | 107 |
| abstract_inverted_index.introduce | 128 |
| abstract_inverted_index.metabolic | 120 |
| abstract_inverted_index.profiles. | 78 |
| abstract_inverted_index.promising | 32, 102 |
| abstract_inverted_index.protease, | 23 |
| abstract_inverted_index.retaining | 123 |
| abstract_inverted_index.stability | 121 |
| abstract_inverted_index.sulfamate | 71, 129 |
| abstract_inverted_index.acetamides | 130 |
| abstract_inverted_index.alphavirus | 28 |
| abstract_inverted_index.identified | 66 |
| abstract_inverted_index.inhibitors | 38, 68, 139 |
| abstract_inverted_index.reactivity | 47 |
| abstract_inverted_index.alternative | 62 |
| abstract_inverted_index.biochemical | 75 |
| abstract_inverted_index.glutathione | 46, 54 |
| abstract_inverted_index.reactivity, | 96 |
| abstract_inverted_index.underscores | 11 |
| abstract_inverted_index.alphaviruses | 4 |
| abstract_inverted_index.encephalitis | 10 |
| abstract_inverted_index.liabilities, | 59 |
| abstract_inverted_index.replication, | 29 |
| abstract_inverted_index.selectivity. | 99 |
| abstract_inverted_index.alphaviruses, | 93 |
| abstract_inverted_index.direct-acting | 141 |
| abstract_inverted_index.electrophilic | 63 |
| abstract_inverted_index.modifications | 117 |
| abstract_inverted_index.proteome-wide | 98 |
| abstract_inverted_index.therapeutics. | 18 |
| abstract_inverted_index.<i>N</i>-alkyl | 70 |
| abstract_inverted_index.antialphaviral | 103 |
| abstract_inverted_index.broad-spectrum | 16 |
| abstract_inverted_index.mosquito-borne | 3 |
| abstract_inverted_index.pan-alphavirus | 142 |
| abstract_inverted_index.methylsulfamate | 80, 106 |
| abstract_inverted_index.glucuronidation. | 113 |
| abstract_inverted_index.species-dependent | 49 |
| abstract_inverted_index.Structure-activity | 114 |
| abstract_inverted_index.<i>S</i>-transferase. | 55 |
| abstract_inverted_index.2-((5-(2-Ethoxyphenyl)-1<i>H</i>-pyrazol-3-yl)amino)-2-oxoethyl | 79 |
| abstract_inverted_index.2-((5-(2-ethoxyphenyl)-1<i>H</i>-pyrazol-3-yl)amino)-2-oxoethyl | 105 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 15 |
| citation_normalized_percentile.value | 0.90891516 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |