ADRB2 gene polymorphisms and salbutamol responsiveness in Serbian children with asthma Article Swipe
Nevena Jovičić
,
Tamara Babič
,
Sandra Dragičević
,
Branimir Nestorović
,
Aleksandra Nikolić
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.2478/bjmg-2018-0007
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.2478/bjmg-2018-0007
Inhaled β2 adrenergic receptor (β2-AR) agonists are the mainstay of asthma therapy. The β2-AR protein is encoded by the ADRB2 gene and variants within this gene can have significant consequences for modulating the response to asthma therapy. This cross-sectional study performed at the University Children’s Hospital in Belgrade, included 54 children with asthma. The subjects were genotyped for ADRB2 +46A>G (Arg16Gly, rs1042713) and +79C>G (Gln27Glu, rs 1042714) polymorphisms and the association with asthma severity and response to inhaled salbutamol was examined. In Serbian asthmatic children, allele +46A was detected with a frequency of 41.7% and allele +79G was detected with a frequency of 23.1%. Allele +46G was found to be associated with a better response to inhaled salbutamol ( p <0.05) and with mild form of asthma ( p <0.05). Polymorphism ADRB2 +46A>G may be a determinant of asthma severity and response to salbutamol in children with asthma. We did not find any association of +79C>G polymorphisms with the asthma severity and bronchodilator response to inhaled salbutamol. The results of this study can be potentially useful for personalization of asthma treatment.
Related Topics
Concepts
Salbutamol
Asthma
Medicine
Allele
Bronchodilator
Polymorphism (computer science)
Pediatrics
Pharmacology
Internal medicine
Gene
Genetics
Biology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2478/bjmg-2018-0007
- https://content.sciendo.com/downloadpdf/journals/bjmg/21/1/article-p33.pdf
- OA Status
- gold
- Cited By
- 9
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2898706276
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2898706276Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2478/bjmg-2018-0007Digital Object Identifier
- Title
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ADRB2 gene polymorphisms and salbutamol responsiveness in Serbian children with asthmaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2018Year of publication
- Publication date
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2018-06-01Full publication date if available
- Authors
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Nevena Jovičić, Tamara Babič, Sandra Dragičević, Branimir Nestorović, Aleksandra NikolićList of authors in order
- Landing page
-
https://doi.org/10.2478/bjmg-2018-0007Publisher landing page
- PDF URL
-
https://content.sciendo.com/downloadpdf/journals/bjmg/21/1/article-p33.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://content.sciendo.com/downloadpdf/journals/bjmg/21/1/article-p33.pdfDirect OA link when available
- Concepts
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Salbutamol, Asthma, Medicine, Allele, Bronchodilator, Polymorphism (computer science), Pediatrics, Pharmacology, Internal medicine, Gene, Genetics, BiologyTop concepts (fields/topics) attached by OpenAlex
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9Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2023: 1, 2022: 1, 2021: 2, 2020: 4Per-year citation counts (last 5 years)
- References (count)
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26Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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