Iatrogenic Kaposi’s sarcoma in myasthenia gravis: learnings from two case reports Article Swipe
Rita Frangiamore
,
Riccardo Giossi
,
Fiammetta Vanoli
,
Athanasia Tourlaki
,
Lucia Brambilla
,
Lorenzo Maggi
,
Renato Mantegazza
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1007/s10072-020-04971-9
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1007/s10072-020-04971-9
Introduction Myasthenia gravis (MG) is an autoimmune neuromuscular disease whose treatment encompasses acetylcholinesterase inhibitors, oral steroids, and other immunosuppressants. Kaposi’s sarcoma (KS) is a lymphangioproliferative disease associated with human herpesvirus 8 (HHV-8) infection and immunodeficiency or immunosuppression, mainly corticosteroids. Case reports We present two cases of MG patients treated with oral steroids who developed KS. Patient 1 was diagnosed with three oral KS lesions. Prednisone was discontinued with lesion regression and stabilization, while azathioprine and pyridostigmine prompted control of MG. Patient 2 developed KS lesions on the trunk and lower limbs while taking prednisone and azathioprine. Steroid tapering was started but new oral and lymph nodal lesions appeared. Paclitaxel therapy was introduced and the patient experienced pulmonary embolism and developed sensitive neuropathy. Complete remission of KS lesions was achieved and maintained with azathioprine and pyridostigmine as MG medications. Conclusions KS is an uncommon but clinically relevant adverse event (AE) often induced by steroid therapy. It can be controlled by steroid withdrawal but could necessitate chemotherapy, which associates with further potential AEs. Skin evaluation should be performed in all patients with chronic steroid therapy. Steroid-sparing strategies, including new drugs, could reduce KS and other steroid-related comorbidities. HHV-8 testing should be considered before starting chronic immunosuppression.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s10072-020-04971-9
- https://link.springer.com/content/pdf/10.1007/s10072-020-04971-9.pdf
- OA Status
- hybrid
- Cited By
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- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W3118855710
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Raw OpenAlex JSON
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https://openalex.org/W3118855710Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1007/s10072-020-04971-9Digital Object Identifier
- Title
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Iatrogenic Kaposi’s sarcoma in myasthenia gravis: learnings from two case reportsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-01-06Full publication date if available
- Authors
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Rita Frangiamore, Riccardo Giossi, Fiammetta Vanoli, Athanasia Tourlaki, Lucia Brambilla, Lorenzo Maggi, Renato MantegazzaList of authors in order
- Landing page
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https://doi.org/10.1007/s10072-020-04971-9Publisher landing page
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https://link.springer.com/content/pdf/10.1007/s10072-020-04971-9.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://link.springer.com/content/pdf/10.1007/s10072-020-04971-9.pdfDirect OA link when available
- Concepts
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Myasthenia gravis, Medicine, Neuroradiology, Neurosurgery, Neurology, Sarcoma, Dermatology, Surgery, Pathology, Internal medicine, PsychiatryTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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