CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer Article Swipe
Esperanza Martín‐Sánchez
,
Saioa Mendaza
,
Ane Ulazia-Garmendia
,
Iñaki Monreal‐Santesteban
,
Idoia Blanco‐Luquin
,
Alicia Córdoba
,
Francisco Vicente-García
,
Noemí Pérez‐Janices
,
David Escors
,
Diego Megı́as
,
Paula López-Serra
,
Manel Esteller
,
José Juan Illarramendi
,
David Guerrero‐Setas
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.15004
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.15004
The CHL1 gene encodes a cell-adhesion molecule proposed as being a putative tumour-suppressor gene in breast cancer (BC). However, neither the underlying molecular mechanisms nor the clinical value of CHL1 downregulation in BC has been explored. The methylation status of three CpG sites in the CHL1 promoter was analysed by pyrosequencing in neoplastic biopsies from 142 patients with invasive BC and compared with that of non-neoplastic tissues. We found higher CHL1 methylation levels in breast tumours than in non-neoplastic tissues, either from mammoplasties or adjacent-to-tumour, which correlated with lower levels of protein expression in tumours measured by immunohistochemistry. A panel of five BC cell lines was treated with two epigenetic drugs, and restoration of CHL1 expression was observed, indicating in vitro dynamic epigenetic regulation. CHL1 was silenced by shRNA in immortalized but non-neoplastic mammary cells, and enhanced cell proliferation and migration, but not invasion, were found by real-time cell analysis. The prognostic value of CHL1 hypermethylation was assessed by the log-rank test and fitted in a Cox regression model. Importantly, CHL1 hypermethylation was very significantly associated with shorter progression-free survival in our BC patient series, independent of age and stage (p = 0.001). In conclusion, our results indicate that CHL1 is downregulated by hypermethylation and that this epigenetic alteration is an independent prognostic factor in BC.
Related Topics
Concepts
DNA methylation
Epigenetics
CpG site
Cancer research
Biology
Breast cancer
Methylation
Immunohistochemistry
Cancer
Biomarker
Pathology
Medicine
Gene expression
Gene
Immunology
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.18632/oncotarget.15004
- http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15004&path%5B%5D=47940
- OA Status
- diamond
- Cited By
- 33
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2584675521
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2584675521Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.18632/oncotarget.15004Digital Object Identifier
- Title
-
CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancerWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-02-02Full publication date if available
- Authors
-
Esperanza Martín‐Sánchez, Saioa Mendaza, Ane Ulazia-Garmendia, Iñaki Monreal‐Santesteban, Idoia Blanco‐Luquin, Alicia Córdoba, Francisco Vicente-García, Noemí Pérez‐Janices, David Escors, Diego Megı́as, Paula López-Serra, Manel Esteller, José Juan Illarramendi, David Guerrero‐SetasList of authors in order
- Landing page
-
https://doi.org/10.18632/oncotarget.15004Publisher landing page
- PDF URL
-
https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15004&path%5B%5D=47940Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=15004&path%5B%5D=47940Direct OA link when available
- Concepts
-
DNA methylation, Epigenetics, CpG site, Cancer research, Biology, Breast cancer, Methylation, Immunohistochemistry, Cancer, Biomarker, Pathology, Medicine, Gene expression, Gene, Immunology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
33Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2023: 2, 2022: 3, 2021: 6, 2020: 5Per-year citation counts (last 5 years)
- References (count)
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43Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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