High speed intravascular photoacoustic imaging with fast optical parametric oscillator laser at 1.7 μm Article Swipe

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Intravascular ultrasound Materials science Photoacoustic imaging in biomedicine Imaging phantom Laser Optical parametric oscillator Optics Photoacoustic Doppler effect Biomedical engineering Optoelectronics Wavelength Radiology Medicine Physics

Zhonglie Piao , Teng Ma , Jiawen Li , Maximilian Wiedmann , Shenghai Huang , Mingyue Yu , K. Kirk Shung , Qifa Zhou , Chang‐Seok Kim , Zhongping Chen ·

YOU? · · 2015 · Open Access · · DOI: https://doi.org/10.1063/1.4929584 · OA: W1933457697

Intravascular photoacoustic imaging at 1.7 μm spectral band has shown promising capabilities for lipid-rich vulnerable atherosclerotic plaque detection. In this work, we report a high speed catheter-based integrated intravascular photoacoustic/intravascular ultrasound (IVPA/IVUS) imaging system with a 500 Hz optical parametric oscillator laser at 1725 nm. A lipid-mimicking phantom and atherosclerotic rabbit abdominal aorta were imaged at 1 frame per second, which is two orders of magnitude faster than previously reported in IVPA imaging with the same wavelength. Clear photoacoustic signals by the absorption of lipid rich deposition demonstrated the ability of the system for high speed vulnerable atherosclerotic plaques detection.