Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements Article Swipe

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Limb development GLI3 Sonic hedgehog Progenitor cell Mesoderm Biology Progenitor Anatomy Limb bud Lateral plate mesoderm Cell biology Genetics Transcription factor Gene Embryonic stem cell Embryo Stem cell Signal transduction Repressor

Ryutaro Akiyama , Hiroko Kawakami , Julia Wong , Isao Oishi , Ryuichi Nishinakamura , Yasuhiko Kawakami ·

YOU? · · 2015 · Open Access · · DOI: https://doi.org/10.1073/pnas.1421949112 · OA: W2056783276

Significance The limb skeletal elements that have unique morphology and distinct locations are developed from limb progenitors, derived from the lateral plate mesoderm. These skeletal elements arise during limb development. In this study, we show genetic evidence that function of Sall4 is essential prior to limb outgrowth for development of the anterior-proximal skeletal elements. Furthermore, genetic interaction between Sall4 and Gli3 is upstream of establishing Shh (Sonic hedgehog) expression, and therefore, Shh -dependent posterior skeletal elements. Our study identified early requirements of the Sall4-Gli3 system for two putative progenitor pools that develop into distinct sets of limb skeletal elements.