The mammalian blastema: regeneration at our fingertips Article Swipe
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Jennifer Simkin
,
Mimi C. Sammarco
,
Lindsay Dawson
,
Paula P. Schanes
,
Ling Yu
,
Ken Muneoka
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1002/reg2.36
· OA: W2084087844
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1002/reg2.36
· OA: W2084087844
In the mouse, digit tip regeneration progresses through a series of discrete stages that include inflammation, histolysis, epidermal closure, blastema formation, and redifferentiation. Recent studies reveal how each regenerative stage influences subsequent stages to establish a blastema that directs the successful regeneration of a complex mammalian structure. The focus of this review is on early events of healing and how an amputation wound transitions into a functional blastema. The stepwise formation of a mammalian blastema is proposed to provide a model for how specific targeted treatments can enhance regenerative performance in humans.
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