Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP Article Swipe
Related Concepts
Mitochondrial permeability transition pore
MPTP
Acinar cell
Pharmacology
Chemistry
Acute pancreatitis
Mitophagy
Pancreatitis
Programmed cell death
Endocrinology
Biology
Autophagy
Internal medicine
Medicine
Biochemistry
Apoptosis
Dopamine
Dopaminergic
Rajarshi Mukherjee
,
Olga A. Mareninova
,
Irina Odinokova
,
Wei Huang
,
John Murphy
,
Michael Chvanov
,
Muhammad A. Javed
,
Li Wen
,
David M. Booth
,
Matthew C. Cane
,
Muhammad Awais
,
Bruno Gavillet
,
Rebecca M. Pruss
,
Sophie Schaller
,
Jeffery D. Molkentin
,
Alexei V. Tepikin
,
Ole H. Petersen
,
Stephen J. Pandol
,
Ilya Gukovsky
,
David N. Criddle
,
Anna S. Gukovskaya
,
Robert Sutton
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1136/gutjnl-2014-308553
· OA: W2113079755
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1136/gutjnl-2014-308553
· OA: W2113079755
This work demonstrates the mechanism and consequences of MPTP opening to be fundamental to multiple forms of acute pancreatitis and validates the MPTP as a drug target for this disease.
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