Microfluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low‐Viscosity Bioink Article Swipe

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3D bioprinting Microfluidics Materials science Nanotechnology Extrusion Computer science Viscosity Tissue engineering Biomedical engineering Engineering Composite material

Cristina Colosi , Su Ryon Shin , Vijayan Manoharan , Solange Massa , Marco Costantini , Andrea Barbetta , Mehmet R. Dokmeci , Mariella Dentini , Ali Khademhosseini ·

YOU? · · 2015 · Open Access · · DOI: https://doi.org/10.1002/adma.201503310 · OA: W2174690427

A novel bioink and a dispensing technique for 3D tissue-engineering applications are presented. The technique incorporates a coaxial extrusion needle using a low-viscosity cell-laden bioink to produce highly defined 3D biostructures. The extrusion system is then coupled to a microfluidic device to control the bioink arrangement deposition, demonstrating the versatility of the bioprinting technique. This low-viscosity cell-responsive bioink promotes cell migration and alignment within each fiber organizing the encapsulated cells.