Regioselective Copper‐Catalyzed Oxidative Cross‐Coupling of Imidazo[1,2‐a]pyridines with Methyl Ketones: An Efficient Route for Synthesis of 1,2‐Diketones Article Swipe

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Chemistry Regioselectivity Catalysis Oxidative coupling of methane Pyridine Oxidative phosphorylation Copper Oxygen Molecular oxygen Environmentally friendly Medicinal chemistry Organic chemistry Combinatorial chemistry Ecology Biology Biochemistry

Sai Lei , Guijun Chen , Yingying Mai , Longbin Chen , Huiyin Cai , Jingwen Tan , Hua Cao ·

YOU? · · 2015 · Open Access · · DOI: https://doi.org/10.1002/adsc.201500803 · OA: W2201316907

An efficient copper‐catalyzed oxidative coupling of imidazo[1,2‐ a ]pyridines with methyl ketones to directly generate structurally sophisticated 1,2‐dicarbonyl imidazo[1,2‐ a ]pyridine derivatives under oxidative conditions is described. The reaction proceeds in good yields using the environmental friendly molecular oxygen as the oxidant. 18 O‐Labelling experiments unambiguously established that the oxygen of the dicarbonyl products originated from oxygen rather than from water. magnified image