Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress Article Swipe

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Autophagy Endoplasmic reticulum Unfolded protein response Homeostasis Acinar cell Pancreas Cell biology Basal (medicine) Pancreatic cancer Reactive oxygen species Pancreatitis Biology Internal medicine Apoptosis Endocrinology Medicine Biochemistry Cancer Diabetes mellitus

Laura Antonucci , Johan Bourghardt Fagman , Ju Youn Kim , Jelena Todoric , Ilya Gukovsky , Mason Mackey , Mark H. Ellisman , Michael Karin ·

YOU? · · 2015 · Open Access · · DOI: https://doi.org/10.1073/pnas.1519384112 · OA: W2249366289

Significance This work identifies autophagy as an essential homeostatic process that maintains pancreatic acinar cell function. By preventing endoplasmic reticulum stress, reactive oxygen species accumulation, and DNA damage, basal autophagy preserves the high rates of protein synthesis that characterize the exocrine pancreas. Conversely, loss of autophagy can result in progressive loss of pancreatic function, which leads to development of pancreatitis as well as regenerative responses that may increase the risk of pancreatic cancer.