Contact Bioassays with Phenoxybenzyl and Tetrafluorobenzyl Pyrethroids against Target-Site and Metabolic Resistant Mosquitoes Article Swipe

PDF

Related Concepts

Piperonyl butoxide Deltamethrin Pyrethroid Permethrin Biology Indoor residual spraying Toxicology Knockdown resistance Anopheles gambiae Bendiocarb Bioassay Aedes aegypti Cyfluthrin Pharmacology Malaria Pesticide Plasmodium falciparum Genetics Ecology Artemisinin Immunology Larva

Sebastian Horstmann , Rainer Sonneck ·

YOU? · · 2016 · Open Access · · DOI: https://doi.org/10.1371/journal.pone.0149738 · OA: W2290465716

The results of this study suggest that transfluthrin has the potential to control P450-mediated metabolically resistant mosquitoes because the structural formula of transfluthrin differs from that of the tested pyrethroids, which are used in vector control. The P450-detoxifying enzymes of the Anopheles funestus FUMOZ-R mosquitoes seem to bind preferably at the phenoxybenzyl moiety and appear to be unable to degrade transfluthrin with its tetrafluorobenzyl moiety. Inhibition of the class of monooxygenases by piperonyl butoxide revealed no increase of efficacy of the pure transfluthrin compound, which also indicates that the P450 enzymes potentially do not impact the efficacy of transfluthrin.