Mechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies Article Swipe
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Markus Dick
,
Rudolf Hartmann
,
Oliver H. Weiergräber
,
Carolin Bisterfeld
,
Thomas Claßen
,
Melanie Schwarten
,
Philipp Neudecker
,
Dieter Willbold
,
Jörg Pietruszka
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1039/c5sc04574f
· OA: W2332859617
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1039/c5sc04574f
· OA: W2332859617
Understanding the deactivation mechanism of 2-deoxy- d -ribose-5-phosphate aldolase by its natural substrate leads to a single mutant showing complete acetaldehyde resistance.
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