Molecular architecture of the inner ring scaffold of the human nuclear pore complex Article Swipe

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nuclear pore nucleus cytoplasm macromolecule ring (chemistry) inner membrane biophysics nucleoporin chemistry crystallography materials science cell nucleus membrane nuclear transport cell biology biology biochemistry organic chemistry

Jan Kosiński , Shyamal Mosalaganti , Alexander von Appen , Roman Teimer , Amanda L. DiGuilio , William Wan , Khanh Huy Bui , Wim J. H. Hagen , John A. G. Briggs , Joseph S. Glavy , Ed Hurt , Martin Beck ·

YOU? · · 2016 · Open Access · · DOI: https://doi.org/10.1126/science.aaf0643 · OA: W2335825911

Blueprint for a macromolecular machine Nuclear pore complexes (NPCs) consist of around 1000 protein subunits, are embedded in the membrane that surrounds the nucleus, and regulate transport between the nucleus and the cytoplasm. Although the overall shape of NPCs is known, the details of this macromolecular complex have been obscure. Now, Lin et al. have reconstituted the pore components, determined the interactions between them, and fitted them into a tomographic reconstruction. Kosinski et al. have provided an architectural map of the inner ring of the pore. Science , this issue pp. 10.1126/science.aaf1015 and 363