Midazolam for sedation before procedures Article Swipe

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Aaron Conway , John Rolley , Joanna Sutherland ·

YOU? · · 2016 · Open Access · · DOI: https://doi.org/10.1002/14651858.cd009491.pub2 · OA: W2402544400

We found no high-quality evidence to determine if midazolam, when administered as the sole sedative agent prior to a procedure, produces more or less effective sedation than placebo or other medications. There is low-quality evidence that intravenous midazolam reduced anxiety when compared with placebo. There is inconsistent evidence that oral midazolam decreased anxiety during procedures compared with placebo. Intranasal midazolam did not reduce the risk of incomplete procedures, although anxiolysis and sedation were observed. There is moderate-quality evidence suggesting that oral midazolam produces less effective sedation than chloral hydrate for completion of procedures for children undergoing non-invasive diagnostic procedures.