Stem Cell–Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy Article Swipe

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Retinitis pigmentosa Photoreceptor cell Retinal degeneration Biology Transplantation Cell biology Retina Rhodopsin Retinal regeneration Induced pluripotent stem cell Stem cell Retinal Ribbon synapse Regeneration (biology) Visual phototransduction Embryonic stem cell Pathology Neuroscience Medicine Genetics Internal medicine Synaptic vesicle Biochemistry Membrane Vesicle Gene

Tiago Santos‐Ferreira , Manuela Völkner , Oliver Borsch , Jochen Haas , Peter Cimalla , Praveen Vasudevan , Peter Carmeliet , Denis Corbeil , Stylianos Michalakis , Edmund Koch , Michael Karl , Marius Ader ·

YOU? · · 2016 · Open Access · · DOI: https://doi.org/10.1167/iovs.16-19087 · OA: W2470420774

Comparison of photoreceptor grafts in preclinical models with incomplete or complete photoreceptor loss, showed differential transplant success with effective and impaired integration, respectively. Thus, Cpfl1/Rho-/- mice represent a potential benchmark model resembling patients with severe retinal degeneration to optimize photoreceptor replacement therapies.