One‐Pot Preparation of Dimethyl Isosorbide from d‐Sorbitol via Dimethyl Carbonate Chemistry Article Swipe

View

Related Concepts

Dimethyl carbonate Superbase Isosorbide Chemistry Autoclave Yield (engineering) Sorbitol Organic chemistry Catalysis Materials science Metallurgy

Fabio Aricò , Alexander S. Aldoshin , P. Tundo ·

YOU? · · 2016 · Open Access · · DOI: https://doi.org/10.1002/cssc.201601382 · OA: W2560101397

Direct synthesis of dimethyl isosorbide (DMI) from d ‐sorbitol via dimethyl carbonate (DMC) chemistry is herein first reported. High yield of DMI was achieved using the nitrogen superbase 1,5,7‐triazabicyclo[4.4.0]dec‐5‐ene (TBD) as catalyst and performing the reaction in a stainless steel autoclave by increasing the temperature from 90 to 200 °C. In this procedure, DMC features its full capacity acting in the different steps of the process as carboxymethylating, leaving‐group (cyclization), and methylating agent; DMC is also employed as the reaction media.