Super-resolution photoacoustic imaging via flow-induced absorption fluctuations Article Swipe
YOU?
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· 2017
· Open Access
·
· DOI: https://doi.org/10.1364/optica.4.001397
· OA: W2618577570
In deep tissue photoacoustic imaging the spatial resolution is inherently\nlimited by the acoustic wavelength. We present an approach for surpassing the\nacoustic diffraction limit by exploiting temporal fluctuations in the sample\nabsorption distribution, such as those induced by flowing particles. In\naddition to enhanced resolution, our approach inherently provides background\nreduction, and can be implemented with any conventional photoacoustic imaging\nsystem. The considerable resolution increase is made possible by adapting\nnotions from super-resolution optical fluctuations imaging (SOFI) developed for\nblinking fluorescent molecules, to flowing acoustic emitters. By generalizing\nSOFI mathematical analysis to complex valued signals, we demonstrate\nsuper-resolved photoacoustic images that are free from oscillations caused by\nband-limited detection. The presented technique holds potential for\ncontrast-agent free micro-vessels imaging, as red blood cells provide a strong\nendogenous source of naturally fluctuating absorption.\n
