Manganese‐Catalyzed Hydrofunctionalization of Alkenes Article Swipe

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Manganese Hydroboration Catalysis Hydrosilylation Alkoxide Regioselectivity Chemistry Reactivity (psychology) Steric effects Combinatorial chemistry Organic chemistry Alternative medicine Medicine Pathology

Jonathan R. Carney , Barry R. Dillon , Leonie Campbell , Stephen P. Thomas ·

YOU? · · 2018 · Open Access · · DOI: https://doi.org/10.1002/anie.201805483 · OA: W2807861904

The manganese‐catalyzed hydrosilylation and hydroboration of alkenes has been developed using a single manganese(II) precatalyst and reaction protocol. Both reactions proceed with excellent control of regioselectivity and in high yields across a variety of sterically and electronically differentiated substrates (25 examples). Alkoxide activation, using NaO t Bu, was key to precatalyst activation and reactivity. Catalysis was achieved across various functional groups and on gram‐scale for both the developed methodologies with catalysts loadings as low as 0.5 mol %.