A Sequential Study of Age-Related Lipofuscin Accumulation in Hippocampus and Striate Cortex of Rats Article Swipe

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Lipofuscin Microglia Hippocampus NeuN Cortex (anatomy) Biology Cresyl violet Neurodegeneration Neuroscience Cell biology Pathology Immunohistochemistry Staining Medicine Biochemistry Immunology Inflammation Genetics Disease

Sarika Singh Kushwaha , Nisha Patro , Ishan Patro ·

YOU? · · 2018 · Open Access · · DOI: https://doi.org/10.1159/000490908 · OA: W2886301392

The progressive deposition of lipofuscin could result in cellular dysfunction. This encouraged us to forward the idea that microglia not only participate in the removal of the pigment from the neurons but also accumulate these waste products in itself. Such senescent microglia may contribute to age- related neurodegeneration as they lose the neuroprotective potential due to oxidative stress and thus may be unable to effectively phagocytose the age pigment.