No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples Article Swipe

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candidate gene psychology population stratification genetics population depression (economics) moderation gene clinical psychology biology genotype medicine single-nucleotide polymorphism social psychology macroeconomics economics environmental health

Richard Border , Emma C. Johnson , Luke M. Evans , Andrew Smolen , Noah Berley , Patrick F. Sullivan , Matthew C. Keller ·

YOU? · · 2019 · Open Access · · DOI: https://doi.org/10.1176/appi.ajp.2018.18070881 · OA: W2919957599

The study results do not support previous depression candidate gene findings, in which large genetic effects are frequently reported in samples orders of magnitude smaller than those examined here. Instead, the results suggest that early hypotheses about depression candidate genes were incorrect and that the large number of associations reported in the depression candidate gene literature are likely to be false positives.