Single-cell genomics identifies cell type–specific molecular changes in autism Article Swipe

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autism neocortex transcriptome biology neuroscience genomics cell type microglia neural cell neural stem cell cell gene genetics genome gene expression psychology stem cell psychiatry immunology inflammation

Dmitry Velmeshev , Lucas Schirmer , Diane Jung , Maximilian Haeussler , Yonatan Perez , Simone Mayer , Aparna Bhaduri , Nitasha Goyal , David H. Rowitch , Arnold R. Kriegstein ·

YOU? · · 2019 · Open Access · · DOI: https://doi.org/10.1126/science.aav8130 · OA: W2946016273

Brain cell transcriptomes in autism Autism manifests in many ways. Despite that diversity, the disorder seems to affect specific cellular pathways, including those observed in the neocortex of patients' brains. Velmeshev et al. analyzed the transcriptomes of single brain cells, including neurons and glia, from patients with autism. Single-nucleus RNA sequencing analysis suggested that affected pathways regulate synapse function as well as neural outgrowth and migration. Furthermore, in patient samples, specific sets of genes enriched in upper-layer projection neurons and microglia correlated with clinical severity. Science , this issue p. 685