Ferroptosis inhibitor alleviates Radiation-induced lung fibrosis (RILF) via down-regulation of TGF-β1 Article Swipe
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Xuan Li
,
Lijie Duan
,
Sujuan Yuan
,
Xibing Zhuang
,
Tiankui Qiao
,
Jian He
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1186/s12950-019-0216-0
· OA: W2947494849
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1186/s12950-019-0216-0
· OA: W2947494849
Our data suggested that ferroptosis played a critical role in RILF, ferroptosis inhibitor liproxstatin-1 alleviated RILF via down-regulation of TGF-β1 by the activation of Nrf2 pathway. The effectiveness of ferroptosis inhibition on RILF provides a novel therapeutic target for RILF.
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