Genetic Variants Associated With Corneal Biomechanical Properties and Potentially Conferring Susceptibility to Keratoconus in a Genome-Wide Association Study Article Swipe
Related Concepts
Keratoconus
Medicine
Genome-wide association study
Corneal Diseases
Genetics
Genome
Genetic association
Ophthalmology
Cornea
Genotype
Single-nucleotide polymorphism
Biology
Gene
Anthony P. Khawaja
,
Karla E. Rojas López
,
Alison J. Hardcastle
,
Christopher J. Hammond
,
Petra Lišková
,
Alice E. Davidson
,
Daniel M. Gore
,
Nathaniel J. Hafford‐Tear
,
Nikolas Pontikos
,
Shabina Hayat
,
Nicholas J. Wareham
,
Kay‐Tee Khaw
,
Stephen J. Tuft
,
Paul J. Foster
,
Pirro G. Hysi
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1001/jamaophthalmol.2019.2058
· OA: W2956067155
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1001/jamaophthalmol.2019.2058
· OA: W2956067155
Five loci that are associated with corneal biomechanical properties and that have suggestive associations with keratoconus were reported. These findings suggest the role of type VI collagen, extracellular matrix, and connective-tissue development for corneal biomechanics and keratoconus and the role of CH and CRF as biomarkers for keratoconus.
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