Cell entry mechanisms of SARS-CoV-2 Article Swipe

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furin proteases viral entry biology receptor coronavirus cell biology virology protease cell virus coronavirus disease 2019 (covid-19) enzyme biochemistry viral replication medicine disease pathology infectious disease (medical specialty)

Jian Shang , Yushun Wan , Chuming Luo , Gang Ye , Qibin Geng , Ashley A. Auerbach , Fang Li ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.1073/pnas.2003138117 · OA: W3022435472

Significance A key to curbing SARS-CoV-2 is to understand how it enters cells. SARS-CoV-2 and SARS-CoV both use human ACE2 as entry receptor and human proteases as entry activators. Using biochemical and pseudovirus entry assays and SARS-CoV as a comparison, we have identified key cell entry mechanisms of SARS-CoV-2 that potentially contribute to the immune evasion, cell infectivity, and wide spread of the virus. This study also clarifies conflicting reports from recent studies on cell entry of SARS-CoV-2. Finally, by highlighting the potency and the evasiveness of SARS-CoV-2, the study provides insight into intervention strategies that target its cell entry mechanisms.