Mucoid Pseudomonas aeruginosa Can Produce Calcium-Gelled Biofilms Independent of the Matrix Components Psl and CdrA Article Swipe

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Biology Biofilm Pseudomonas aeruginosa Microbiology Calcium PSL Matrix (chemical analysis) Bacteria Chromatography Materials science Chemistry Genetics Geometry Metallurgy Mathematics

Holly M. Jacobs , Lindsey O’Neal , Edward D. B. Lopatto , Daniel J. Wozniak , Thomas Bjarnsholt , Matthew R. Parsek ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.1128/jb.00568-21 · OA: W4223490132

The opportunistic pathogen Pseudomonas aeruginosa produces a complex biofilm matrix comprised of exopolysaccharides (EPSs), nucleic acids, and proteins. P. aeruginosa biofilm formation canonically depends on a variable combination of the exopolysaccharides Psl and Pel and the matrix protein CdrA. We demonstrate that mucoid P. aeruginosa , which overproduces the EPS alginate, possesses an entirely alternate and calcium-dependent method of biofilm formation.