Identification and characterization of human GDF15 knockouts Article Swipe
Allan Gurtan
,
Shareef Khalid
,
Christopher Koch
,
Maleeha Khan
,
Lindsey B. Lamarche
,
Elizabeth M. Dolan
,
Ana M. Carrion
,
Richard Zessis
,
Matthew E. Clement
,
Zhiping Chen
,
Loren Lindsley
,
Yu‐Hsin Chiu
,
Ryan S. Streeper
,
Daniel P. Denning
,
Allison B. Goldfine
,
Brian Doyon
,
Ali Abbasi
,
Jennifer Harrow
,
Kazuhisa Tsunoyama
,
Makoto Asaumi
,
Ikuyo Kou
,
Alan R. Shuldiner
,
Juan L. Rodríguez-Flores
,
Asif Rasheed
,
Muhammad Jahanzaib
,
Muhammad Rehan Mian
,
Muhammad Bilal Liaqat
,
Syed Shahzaib Raza
,
Riffat Sultana
,
Anjum Jalal
,
Muhammad Hamid Saeed
,
Shahid Abbas
,
Fazal Rehman Memon
,
Muhammad Ishaq
,
John Dominy
,
Danish Saleheen
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.03.14.24303793
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.03.14.24303793
Growth differentiation factor 15 (GDF15) is a secreted protein that regulates food intake, body weight, and stress responses in pre-clinical models 1 . The physiological function of GDF15 in humans remains unclear. Pharmacologically, GDF15 agonism in humans caused nausea without accompanying weight loss 2 , and the effect of GDF15 antagonism is being tested in clinical trials to treat cachexia and anorexia. Human genetics point to a role for GDF15 in hyperemesis gravidarum, but the safety or impact of complete GDF15 loss, particularly during pregnancy, is unknown 3–7 . Here, we characterize GDF15 loss-of-function carriers (LOF), including 5 homozygous null carriers (“knockouts”) from 75,018 participants enrolled in the Pakistan Genomic Resource (PGR) 8,9 . We tested for the association of GDF15 LOF with 97 quantitative traits and binary outcomes. Further, 3 additional knockouts and 59 heterozygous carriers were identified in recall-by-genotype (RBG) studies accompanied by recruitment of family members. GDF15 knockouts ranged in age from 31 to 75 years, were fertile, and showed no consistent overt metabolic dysfunction. Collectively, our data indicate that (i) complete GDF15 loss is compatible with life and fertility, (ii) chronic therapeutic inhibition of GDF15 may be tolerated, and (iii) GDF15 modulation may not significantly impact body weight or metabolic syndrome.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.03.14.24303793
- https://www.medrxiv.org/content/medrxiv/early/2024/03/18/2024.03.14.24303793.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392966521
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4392966521Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2024.03.14.24303793Digital Object Identifier
- Title
-
Identification and characterization of human GDF15 knockoutsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-18Full publication date if available
- Authors
-
Allan Gurtan, Shareef Khalid, Christopher Koch, Maleeha Khan, Lindsey B. Lamarche, Elizabeth M. Dolan, Ana M. Carrion, Richard Zessis, Matthew E. Clement, Zhiping Chen, Loren Lindsley, Yu‐Hsin Chiu, Ryan S. Streeper, Daniel P. Denning, Allison B. Goldfine, Brian Doyon, Ali Abbasi, Jennifer Harrow, Kazuhisa Tsunoyama, Makoto Asaumi, Ikuyo Kou, Alan R. Shuldiner, Juan L. Rodríguez-Flores, Asif Rasheed, Muhammad Jahanzaib, Muhammad Rehan Mian, Muhammad Bilal Liaqat, Syed Shahzaib Raza, Riffat Sultana, Anjum Jalal, Muhammad Hamid Saeed, Shahid Abbas, Fazal Rehman Memon, Muhammad Ishaq, John Dominy, Danish SaleheenList of authors in order
- Landing page
-
https://doi.org/10.1101/2024.03.14.24303793Publisher landing page
- PDF URL
-
https://www.medrxiv.org/content/medrxiv/early/2024/03/18/2024.03.14.24303793.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.medrxiv.org/content/medrxiv/early/2024/03/18/2024.03.14.24303793.full.pdfDirect OA link when available
- Concepts
-
Identification (biology), GDF15, Gene knockout, Characterization (materials science), Business, Genetics, Biology, Gene, Nanotechnology, Materials science, BotanyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
25Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4392966521 |
|---|---|
| doi | https://doi.org/10.1101/2024.03.14.24303793 |
| ids.doi | https://doi.org/10.1101/2024.03.14.24303793 |
| ids.openalex | https://openalex.org/W4392966521 |
| fwci | 2.09891648 |
| type | preprint |
| title | Identification and characterization of human GDF15 knockouts |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T13452 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2745 |
| topics[0].subfield.display_name | Rheumatology |
| topics[0].display_name | GDF15 and Related Biomarkers |
| topics[1].id | https://openalex.org/T10441 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.960099995136261 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Muscle Physiology and Disorders |
| topics[2].id | https://openalex.org/T13991 |
| topics[2].field.id | https://openalex.org/fields/28 |
| topics[2].field.display_name | Neuroscience |
| topics[2].score | 0.9447000026702881 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2804 |
| topics[2].subfield.display_name | Cellular and Molecular Neuroscience |
| topics[2].display_name | Nuclear Receptors and Signaling |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C116834253 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7205665111541748 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q2039217 |
| concepts[0].display_name | Identification (biology) |
| concepts[1].id | https://openalex.org/C136935669 |
| concepts[1].level | 2 |
| concepts[1].score | 0.5629591941833496 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q14912150 |
| concepts[1].display_name | GDF15 |
| concepts[2].id | https://openalex.org/C77957584 |
| concepts[2].level | 3 |
| concepts[2].score | 0.5607993006706238 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1133550 |
| concepts[2].display_name | Gene knockout |
| concepts[3].id | https://openalex.org/C2780841128 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5184478163719177 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q5073781 |
| concepts[3].display_name | Characterization (materials science) |
| concepts[4].id | https://openalex.org/C144133560 |
| concepts[4].level | 0 |
| concepts[4].score | 0.32704126834869385 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q4830453 |
| concepts[4].display_name | Business |
| concepts[5].id | https://openalex.org/C54355233 |
| concepts[5].level | 1 |
| concepts[5].score | 0.10552707314491272 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[5].display_name | Genetics |
| concepts[6].id | https://openalex.org/C86803240 |
| concepts[6].level | 0 |
| concepts[6].score | 0.10277357697486877 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[6].display_name | Biology |
| concepts[7].id | https://openalex.org/C104317684 |
| concepts[7].level | 2 |
| concepts[7].score | 0.0942111611366272 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[7].display_name | Gene |
| concepts[8].id | https://openalex.org/C171250308 |
| concepts[8].level | 1 |
| concepts[8].score | 0.09113624691963196 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q11468 |
| concepts[8].display_name | Nanotechnology |
| concepts[9].id | https://openalex.org/C192562407 |
| concepts[9].level | 0 |
| concepts[9].score | 0.0688939094543457 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q228736 |
| concepts[9].display_name | Materials science |
| concepts[10].id | https://openalex.org/C59822182 |
| concepts[10].level | 1 |
| concepts[10].score | 0.0 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q441 |
| concepts[10].display_name | Botany |
| keywords[0].id | https://openalex.org/keywords/identification |
| keywords[0].score | 0.7205665111541748 |
| keywords[0].display_name | Identification (biology) |
| keywords[1].id | https://openalex.org/keywords/gdf15 |
| keywords[1].score | 0.5629591941833496 |
| keywords[1].display_name | GDF15 |
| keywords[2].id | https://openalex.org/keywords/gene-knockout |
| keywords[2].score | 0.5607993006706238 |
| keywords[2].display_name | Gene knockout |
| keywords[3].id | https://openalex.org/keywords/characterization |
| keywords[3].score | 0.5184478163719177 |
| keywords[3].display_name | Characterization (materials science) |
| keywords[4].id | https://openalex.org/keywords/business |
| keywords[4].score | 0.32704126834869385 |
| keywords[4].display_name | Business |
| keywords[5].id | https://openalex.org/keywords/genetics |
| keywords[5].score | 0.10552707314491272 |
| keywords[5].display_name | Genetics |
| keywords[6].id | https://openalex.org/keywords/biology |
| keywords[6].score | 0.10277357697486877 |
| keywords[6].display_name | Biology |
| keywords[7].id | https://openalex.org/keywords/gene |
| keywords[7].score | 0.0942111611366272 |
| keywords[7].display_name | Gene |
| keywords[8].id | https://openalex.org/keywords/nanotechnology |
| keywords[8].score | 0.09113624691963196 |
| keywords[8].display_name | Nanotechnology |
| keywords[9].id | https://openalex.org/keywords/materials-science |
| keywords[9].score | 0.0688939094543457 |
| keywords[9].display_name | Materials science |
| language | en |
| locations[0].id | doi:10.1101/2024.03.14.24303793 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | https://www.medrxiv.org/content/medrxiv/early/2024/03/18/2024.03.14.24303793.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2024.03.14.24303793 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5027584733 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-1701-7821 |
| authorships[0].author.display_name | Allan Gurtan |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210091341 |
| authorships[0].affiliations[0].raw_affiliation_string | Biomedical Research at Novartis |
| authorships[0].institutions[0].id | https://openalex.org/I4210091341 |
| authorships[0].institutions[0].ror | https://ror.org/00fxgea47 |
| authorships[0].institutions[0].type | company |
| authorships[0].institutions[0].lineage | https://openalex.org/I1283582996, https://openalex.org/I4210091341 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Novartis (China) |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Allan M. Gurtan |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Biomedical Research at Novartis |
| authorships[1].author.id | https://openalex.org/A5103932524 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Shareef Khalid |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I2799503643 |
| authorships[1].affiliations[0].raw_affiliation_string | Columbia University Irving Medical Center |
| authorships[1].institutions[0].id | https://openalex.org/I2799503643 |
| authorships[1].institutions[0].ror | https://ror.org/01esghr10 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I2799503643 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Columbia University Irving Medical Center |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Shareef Khalid |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Columbia University Irving Medical Center |
| authorships[2].author.id | https://openalex.org/A5067327500 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-2754-3385 |
| authorships[2].author.display_name | Christopher Koch |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210091341 |
| authorships[2].affiliations[0].raw_affiliation_string | Biomedical Research at Novartis |
| authorships[2].institutions[0].id | https://openalex.org/I4210091341 |
| authorships[2].institutions[0].ror | https://ror.org/00fxgea47 |
| authorships[2].institutions[0].type | company |
| authorships[2].institutions[0].lineage | https://openalex.org/I1283582996, https://openalex.org/I4210091341 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Novartis (China) |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Christopher Koch |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Biomedical Research at Novartis |
| authorships[3].author.id | https://openalex.org/A5091720512 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-5365-3353 |
| authorships[3].author.display_name | Maleeha Khan |
| authorships[3].countries | PK |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210156882 |
| authorships[3].affiliations[0].raw_affiliation_string | Center for Non-Communicable Diseases |
| authorships[3].institutions[0].id | https://openalex.org/I4210156882 |
| authorships[3].institutions[0].ror | https://ror.org/05xnw5k32 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210156882 |
| authorships[3].institutions[0].country_code | PK |
| authorships[3].institutions[0].display_name | Center for Non-Communicable Diseases |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Maleeha Zaman Khan |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Center for Non-Communicable Diseases |
| authorships[4].author.id | https://openalex.org/A5013310768 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-7200-3150 |
| authorships[4].author.display_name | Lindsey B. Lamarche |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210091341 |
| authorships[4].affiliations[0].raw_affiliation_string | Biomedical Research at Novartis |
| authorships[4].institutions[0].id | https://openalex.org/I4210091341 |
| authorships[4].institutions[0].ror | https://ror.org/00fxgea47 |
| authorships[4].institutions[0].type | company |
| authorships[4].institutions[0].lineage | https://openalex.org/I1283582996, https://openalex.org/I4210091341 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Novartis (China) |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Lindsey B. Lamarche |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Biomedical Research at Novartis |
| authorships[5].author.id | https://openalex.org/A5053044583 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-2854-3819 |
| authorships[5].author.display_name | Elizabeth M. Dolan |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210091341 |
| authorships[5].affiliations[0].raw_affiliation_string | Biomedical Research at Novartis |
| authorships[5].institutions[0].id | https://openalex.org/I4210091341 |
| authorships[5].institutions[0].ror | https://ror.org/00fxgea47 |
| authorships[5].institutions[0].type | company |
| authorships[5].institutions[0].lineage | https://openalex.org/I1283582996, https://openalex.org/I4210091341 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Novartis (China) |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Elizabeth Dolan |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Biomedical Research at Novartis |
| authorships[6].author.id | https://openalex.org/A5104261238 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Ana M. Carrion |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210091341 |
| authorships[6].affiliations[0].raw_affiliation_string | Biomedical Research at Novartis |
| authorships[6].institutions[0].id | https://openalex.org/I4210091341 |
| authorships[6].institutions[0].ror | https://ror.org/00fxgea47 |
| authorships[6].institutions[0].type | company |
| authorships[6].institutions[0].lineage | https://openalex.org/I1283582996, https://openalex.org/I4210091341 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Novartis (China) |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Ana M. Carrion |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Biomedical Research at Novartis |
| authorships[7].author.id | https://openalex.org/A5090117065 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Richard Zessis |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210091341 |
| authorships[7].affiliations[0].raw_affiliation_string | Biomedical Research at Novartis |
| authorships[7].institutions[0].id | https://openalex.org/I4210091341 |
| authorships[7].institutions[0].ror | https://ror.org/00fxgea47 |
| authorships[7].institutions[0].type | company |
| authorships[7].institutions[0].lineage | https://openalex.org/I1283582996, https://openalex.org/I4210091341 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Novartis (China) |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Richard Zessis |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Biomedical Research at Novartis |
| authorships[8].author.id | https://openalex.org/A5104261239 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Matthew E. Clement |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210091341 |
| authorships[8].affiliations[0].raw_affiliation_string | Biomedical Research at Novartis |
| authorships[8].institutions[0].id | https://openalex.org/I4210091341 |
| authorships[8].institutions[0].ror | https://ror.org/00fxgea47 |
| authorships[8].institutions[0].type | company |
| authorships[8].institutions[0].lineage | https://openalex.org/I1283582996, https://openalex.org/I4210091341 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Novartis (China) |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Matthew E. Clement |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Biomedical Research at Novartis |
| authorships[9].author.id | https://openalex.org/A5100667261 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-3351-5831 |
| authorships[9].author.display_name | Zhiping Chen |
| authorships[9].countries | CN |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210091341 |
| authorships[9].affiliations[0].raw_affiliation_string | Biomedical Research at Novartis |
| authorships[9].institutions[0].id | https://openalex.org/I4210091341 |
| authorships[9].institutions[0].ror | https://ror.org/00fxgea47 |
| authorships[9].institutions[0].type | company |
| authorships[9].institutions[0].lineage | https://openalex.org/I1283582996, https://openalex.org/I4210091341 |
| authorships[9].institutions[0].country_code | CN |
| authorships[9].institutions[0].display_name | Novartis (China) |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Zhiping Chen |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Biomedical Research at Novartis |
| authorships[10].author.id | https://openalex.org/A5017426463 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Loren Lindsley |
| authorships[10].countries | CN |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I4210091341 |
| authorships[10].affiliations[0].raw_affiliation_string | Biomedical Research at Novartis |
| authorships[10].institutions[0].id | https://openalex.org/I4210091341 |
| authorships[10].institutions[0].ror | https://ror.org/00fxgea47 |
| authorships[10].institutions[0].type | company |
| authorships[10].institutions[0].lineage | https://openalex.org/I1283582996, https://openalex.org/I4210091341 |
| authorships[10].institutions[0].country_code | CN |
| authorships[10].institutions[0].display_name | Novartis (China) |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Loren D. Lindsley |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Biomedical Research at Novartis |
| authorships[11].author.id | https://openalex.org/A5071479905 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-4730-8104 |
| authorships[11].author.display_name | Yu‐Hsin Chiu |
| authorships[11].countries | CN |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I4210091341 |
| authorships[11].affiliations[0].raw_affiliation_string | Biomedical Research at Novartis |
| authorships[11].institutions[0].id | https://openalex.org/I4210091341 |
| authorships[11].institutions[0].ror | https://ror.org/00fxgea47 |
| authorships[11].institutions[0].type | company |
| authorships[11].institutions[0].lineage | https://openalex.org/I1283582996, https://openalex.org/I4210091341 |
| authorships[11].institutions[0].country_code | CN |
| authorships[11].institutions[0].display_name | Novartis (China) |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Yu-Hsin Chiu |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Biomedical Research at Novartis |
| authorships[12].author.id | https://openalex.org/A5021878531 |
| authorships[12].author.orcid | https://orcid.org/0009-0007-3429-988X |
| authorships[12].author.display_name | Ryan S. Streeper |
| authorships[12].countries | CN |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I4210091341 |
| authorships[12].affiliations[0].raw_affiliation_string | Biomedical Research at Novartis |
| authorships[12].institutions[0].id | https://openalex.org/I4210091341 |
| authorships[12].institutions[0].ror | https://ror.org/00fxgea47 |
| authorships[12].institutions[0].type | company |
| authorships[12].institutions[0].lineage | https://openalex.org/I1283582996, https://openalex.org/I4210091341 |
| authorships[12].institutions[0].country_code | CN |
| authorships[12].institutions[0].display_name | Novartis (China) |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Ryan S. Streeper |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Biomedical Research at Novartis |
| authorships[13].author.id | https://openalex.org/A5048465477 |
| authorships[13].author.orcid | https://orcid.org/0000-0001-5667-3480 |
| authorships[13].author.display_name | Daniel P. Denning |
| authorships[13].countries | CN |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I4210091341 |
| authorships[13].affiliations[0].raw_affiliation_string | Biomedical Research at Novartis |
| authorships[13].institutions[0].id | https://openalex.org/I4210091341 |
| authorships[13].institutions[0].ror | https://ror.org/00fxgea47 |
| authorships[13].institutions[0].type | company |
| authorships[13].institutions[0].lineage | https://openalex.org/I1283582996, https://openalex.org/I4210091341 |
| authorships[13].institutions[0].country_code | CN |
| authorships[13].institutions[0].display_name | Novartis (China) |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Daniel P. Denning |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Biomedical Research at Novartis |
| authorships[14].author.id | https://openalex.org/A5032424150 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-0345-1048 |
| authorships[14].author.display_name | Allison B. Goldfine |
| authorships[14].countries | CN |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I4210091341 |
| authorships[14].affiliations[0].raw_affiliation_string | Biomedical Research at Novartis |
| authorships[14].institutions[0].id | https://openalex.org/I4210091341 |
| authorships[14].institutions[0].ror | https://ror.org/00fxgea47 |
| authorships[14].institutions[0].type | company |
| authorships[14].institutions[0].lineage | https://openalex.org/I1283582996, https://openalex.org/I4210091341 |
| authorships[14].institutions[0].country_code | CN |
| authorships[14].institutions[0].display_name | Novartis (China) |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Allison B. Goldfine |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Biomedical Research at Novartis |
| authorships[15].author.id | https://openalex.org/A5113403356 |
| authorships[15].author.orcid | |
| authorships[15].author.display_name | Brian Doyon |
| authorships[15].countries | US |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I4210088252 |
| authorships[15].affiliations[0].raw_affiliation_string | Tango Therapeutics |
| authorships[15].institutions[0].id | https://openalex.org/I4210088252 |
| authorships[15].institutions[0].ror | https://ror.org/003x6t567 |
| authorships[15].institutions[0].type | company |
| authorships[15].institutions[0].lineage | https://openalex.org/I4210088252 |
| authorships[15].institutions[0].country_code | US |
| authorships[15].institutions[0].display_name | Tango Therapeutics (United States) |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Brian Doyon |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Tango Therapeutics |
| authorships[16].author.id | https://openalex.org/A5011644169 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-6452-4765 |
| authorships[16].author.display_name | Ali Abbasi |
| authorships[16].countries | BR |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I4210116875 |
| authorships[16].affiliations[0].raw_affiliation_string | Centre for Genomics Research at AstraZeneca |
| authorships[16].institutions[0].id | https://openalex.org/I4210116875 |
| authorships[16].institutions[0].ror | https://ror.org/026m9xy48 |
| authorships[16].institutions[0].type | company |
| authorships[16].institutions[0].lineage | https://openalex.org/I105036370, https://openalex.org/I4210116875 |
| authorships[16].institutions[0].country_code | BR |
| authorships[16].institutions[0].display_name | AstraZeneca (Brazil) |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Ali Abbasi |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Centre for Genomics Research at AstraZeneca |
| authorships[17].author.id | https://openalex.org/A5080927998 |
| authorships[17].author.orcid | https://orcid.org/0000-0003-0338-3070 |
| authorships[17].author.display_name | Jennifer Harrow |
| authorships[17].countries | BR |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I4210116875 |
| authorships[17].affiliations[0].raw_affiliation_string | Centre for Genomics Research at AstraZeneca |
| authorships[17].institutions[0].id | https://openalex.org/I4210116875 |
| authorships[17].institutions[0].ror | https://ror.org/026m9xy48 |
| authorships[17].institutions[0].type | company |
| authorships[17].institutions[0].lineage | https://openalex.org/I105036370, https://openalex.org/I4210116875 |
| authorships[17].institutions[0].country_code | BR |
| authorships[17].institutions[0].display_name | AstraZeneca (Brazil) |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Jennifer L. Harrow |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Centre for Genomics Research at AstraZeneca |
| authorships[18].author.id | https://openalex.org/A5088149649 |
| authorships[18].author.orcid | |
| authorships[18].author.display_name | Kazuhisa Tsunoyama |
| authorships[18].countries | CN |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I4210088994 |
| authorships[18].affiliations[0].raw_affiliation_string | Astellas Pharma Inc. |
| authorships[18].institutions[0].id | https://openalex.org/I4210088994 |
| authorships[18].institutions[0].ror | https://ror.org/008h8bh21 |
| authorships[18].institutions[0].type | company |
| authorships[18].institutions[0].lineage | https://openalex.org/I142395110, https://openalex.org/I4210088994 |
| authorships[18].institutions[0].country_code | CN |
| authorships[18].institutions[0].display_name | Astellas Pharma (China) |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Kazuhisa Tsunoyama |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Astellas Pharma Inc. |
| authorships[19].author.id | https://openalex.org/A5004740009 |
| authorships[19].author.orcid | |
| authorships[19].author.display_name | Makoto Asaumi |
| authorships[19].countries | CN |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I4210088994 |
| authorships[19].affiliations[0].raw_affiliation_string | Astellas Pharma Inc. |
| authorships[19].institutions[0].id | https://openalex.org/I4210088994 |
| authorships[19].institutions[0].ror | https://ror.org/008h8bh21 |
| authorships[19].institutions[0].type | company |
| authorships[19].institutions[0].lineage | https://openalex.org/I142395110, https://openalex.org/I4210088994 |
| authorships[19].institutions[0].country_code | CN |
| authorships[19].institutions[0].display_name | Astellas Pharma (China) |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Makoto Asaumi |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Astellas Pharma Inc. |
| authorships[20].author.id | https://openalex.org/A5046227981 |
| authorships[20].author.orcid | |
| authorships[20].author.display_name | Ikuyo Kou |
| authorships[20].countries | CN |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I4210088994 |
| authorships[20].affiliations[0].raw_affiliation_string | Astellas Pharma Inc. |
| authorships[20].institutions[0].id | https://openalex.org/I4210088994 |
| authorships[20].institutions[0].ror | https://ror.org/008h8bh21 |
| authorships[20].institutions[0].type | company |
| authorships[20].institutions[0].lineage | https://openalex.org/I142395110, https://openalex.org/I4210088994 |
| authorships[20].institutions[0].country_code | CN |
| authorships[20].institutions[0].display_name | Astellas Pharma (China) |
| authorships[20].author_position | middle |
| authorships[20].raw_author_name | Ikuyo Kou |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | Astellas Pharma Inc. |
| authorships[21].author.id | https://openalex.org/A5009070946 |
| authorships[21].author.orcid | https://orcid.org/0000-0001-9921-4305 |
| authorships[21].author.display_name | Alan R. Shuldiner |
| authorships[21].countries | US |
| authorships[21].affiliations[0].institution_ids | https://openalex.org/I186523950 |
| authorships[21].affiliations[0].raw_affiliation_string | Regeneron Genetics Center, LLC |
| authorships[21].institutions[0].id | https://openalex.org/I186523950 |
| authorships[21].institutions[0].ror | https://ror.org/02f51rf24 |
| authorships[21].institutions[0].type | company |
| authorships[21].institutions[0].lineage | https://openalex.org/I186523950 |
| authorships[21].institutions[0].country_code | US |
| authorships[21].institutions[0].display_name | Regeneron (United States) |
| authorships[21].author_position | middle |
| authorships[21].raw_author_name | Alan R. Shuldiner |
| authorships[21].is_corresponding | False |
| authorships[21].raw_affiliation_strings | Regeneron Genetics Center, LLC |
| authorships[22].author.id | https://openalex.org/A5059808119 |
| authorships[22].author.orcid | https://orcid.org/0000-0002-0394-8062 |
| authorships[22].author.display_name | Juan L. Rodríguez-Flores |
| authorships[22].countries | US |
| authorships[22].affiliations[0].institution_ids | https://openalex.org/I186523950 |
| authorships[22].affiliations[0].raw_affiliation_string | Regeneron Genetics Center, LLC |
| authorships[22].institutions[0].id | https://openalex.org/I186523950 |
| authorships[22].institutions[0].ror | https://ror.org/02f51rf24 |
| authorships[22].institutions[0].type | company |
| authorships[22].institutions[0].lineage | https://openalex.org/I186523950 |
| authorships[22].institutions[0].country_code | US |
| authorships[22].institutions[0].display_name | Regeneron (United States) |
| authorships[22].author_position | middle |
| authorships[22].raw_author_name | Juan L. Rodriguez-Flores |
| authorships[22].is_corresponding | False |
| authorships[22].raw_affiliation_strings | Regeneron Genetics Center, LLC |
| authorships[23].author.id | https://openalex.org/A5102267738 |
| authorships[23].author.orcid | |
| authorships[23].author.display_name | Asif Rasheed |
| authorships[23].countries | PK |
| authorships[23].affiliations[0].institution_ids | https://openalex.org/I4210156882 |
| authorships[23].affiliations[0].raw_affiliation_string | Center for Non-Communicable Diseases |
| authorships[23].institutions[0].id | https://openalex.org/I4210156882 |
| authorships[23].institutions[0].ror | https://ror.org/05xnw5k32 |
| authorships[23].institutions[0].type | facility |
| authorships[23].institutions[0].lineage | https://openalex.org/I4210156882 |
| authorships[23].institutions[0].country_code | PK |
| authorships[23].institutions[0].display_name | Center for Non-Communicable Diseases |
| authorships[23].author_position | middle |
| authorships[23].raw_author_name | Asif Rasheed |
| authorships[23].is_corresponding | False |
| authorships[23].raw_affiliation_strings | Center for Non-Communicable Diseases |
| authorships[24].author.id | https://openalex.org/A5038614671 |
| authorships[24].author.orcid | https://orcid.org/0000-0002-5101-8564 |
| authorships[24].author.display_name | Muhammad Jahanzaib |
| authorships[24].countries | PK |
| authorships[24].affiliations[0].institution_ids | https://openalex.org/I4210156882 |
| authorships[24].affiliations[0].raw_affiliation_string | Center for Non-Communicable Diseases |
| authorships[24].institutions[0].id | https://openalex.org/I4210156882 |
| authorships[24].institutions[0].ror | https://ror.org/05xnw5k32 |
| authorships[24].institutions[0].type | facility |
| authorships[24].institutions[0].lineage | https://openalex.org/I4210156882 |
| authorships[24].institutions[0].country_code | PK |
| authorships[24].institutions[0].display_name | Center for Non-Communicable Diseases |
| authorships[24].author_position | middle |
| authorships[24].raw_author_name | Muhammad Jahanzaib |
| authorships[24].is_corresponding | False |
| authorships[24].raw_affiliation_strings | Center for Non-Communicable Diseases |
| authorships[25].author.id | https://openalex.org/A5030166853 |
| authorships[25].author.orcid | |
| authorships[25].author.display_name | Muhammad Rehan Mian |
| authorships[25].countries | PK |
| authorships[25].affiliations[0].institution_ids | https://openalex.org/I4210156882 |
| authorships[25].affiliations[0].raw_affiliation_string | Center for Non-Communicable Diseases |
| authorships[25].institutions[0].id | https://openalex.org/I4210156882 |
| authorships[25].institutions[0].ror | https://ror.org/05xnw5k32 |
| authorships[25].institutions[0].type | facility |
| authorships[25].institutions[0].lineage | https://openalex.org/I4210156882 |
| authorships[25].institutions[0].country_code | PK |
| authorships[25].institutions[0].display_name | Center for Non-Communicable Diseases |
| authorships[25].author_position | middle |
| authorships[25].raw_author_name | Muhammad Rehan Mian |
| authorships[25].is_corresponding | False |
| authorships[25].raw_affiliation_strings | Center for Non-Communicable Diseases |
| authorships[26].author.id | https://openalex.org/A5112470199 |
| authorships[26].author.orcid | |
| authorships[26].author.display_name | Muhammad Bilal Liaqat |
| authorships[26].countries | PK |
| authorships[26].affiliations[0].institution_ids | https://openalex.org/I4210156882 |
| authorships[26].affiliations[0].raw_affiliation_string | Center for Non-Communicable Diseases |
| authorships[26].institutions[0].id | https://openalex.org/I4210156882 |
| authorships[26].institutions[0].ror | https://ror.org/05xnw5k32 |
| authorships[26].institutions[0].type | facility |
| authorships[26].institutions[0].lineage | https://openalex.org/I4210156882 |
| authorships[26].institutions[0].country_code | PK |
| authorships[26].institutions[0].display_name | Center for Non-Communicable Diseases |
| authorships[26].author_position | middle |
| authorships[26].raw_author_name | Muhammad Bilal Liaqat |
| authorships[26].is_corresponding | False |
| authorships[26].raw_affiliation_strings | Center for Non-Communicable Diseases |
| authorships[27].author.id | https://openalex.org/A5104261237 |
| authorships[27].author.orcid | |
| authorships[27].author.display_name | Syed Shahzaib Raza |
| authorships[27].countries | PK |
| authorships[27].affiliations[0].institution_ids | https://openalex.org/I4210156882 |
| authorships[27].affiliations[0].raw_affiliation_string | Center for Non-Communicable Diseases |
| authorships[27].institutions[0].id | https://openalex.org/I4210156882 |
| authorships[27].institutions[0].ror | https://ror.org/05xnw5k32 |
| authorships[27].institutions[0].type | facility |
| authorships[27].institutions[0].lineage | https://openalex.org/I4210156882 |
| authorships[27].institutions[0].country_code | PK |
| authorships[27].institutions[0].display_name | Center for Non-Communicable Diseases |
| authorships[27].author_position | middle |
| authorships[27].raw_author_name | Syed Shahzaib Raza |
| authorships[27].is_corresponding | False |
| authorships[27].raw_affiliation_strings | Center for Non-Communicable Diseases |
| authorships[28].author.id | https://openalex.org/A5033616970 |
| authorships[28].author.orcid | https://orcid.org/0000-0003-4775-8452 |
| authorships[28].author.display_name | Riffat Sultana |
| authorships[28].countries | PK |
| authorships[28].affiliations[0].institution_ids | https://openalex.org/I2801307192 |
| authorships[28].affiliations[0].raw_affiliation_string | Karachi Institute of Cardiology |
| authorships[28].institutions[0].id | https://openalex.org/I2801307192 |
| authorships[28].institutions[0].ror | https://ror.org/023grzj16 |
| authorships[28].institutions[0].type | healthcare |
| authorships[28].institutions[0].lineage | https://openalex.org/I2801307192 |
| authorships[28].institutions[0].country_code | PK |
| authorships[28].institutions[0].display_name | Karachi Institute of Heart Diseases |
| authorships[28].author_position | middle |
| authorships[28].raw_author_name | Riffat Sultana |
| authorships[28].is_corresponding | False |
| authorships[28].raw_affiliation_strings | Karachi Institute of Cardiology |
| authorships[29].author.id | https://openalex.org/A5043950478 |
| authorships[29].author.orcid | https://orcid.org/0000-0002-9448-811X |
| authorships[29].author.display_name | Anjum Jalal |
| authorships[29].countries | PK |
| authorships[29].affiliations[0].institution_ids | https://openalex.org/I162547998 |
| authorships[29].affiliations[0].raw_affiliation_string | Punjab Institute of Cardiology |
| authorships[29].institutions[0].id | https://openalex.org/I162547998 |
| authorships[29].institutions[0].ror | https://ror.org/056mnr244 |
| authorships[29].institutions[0].type | healthcare |
| authorships[29].institutions[0].lineage | https://openalex.org/I162547998 |
| authorships[29].institutions[0].country_code | PK |
| authorships[29].institutions[0].display_name | Punjab Institute of Cardiology |
| authorships[29].author_position | middle |
| authorships[29].raw_author_name | Anjum Jalal |
| authorships[29].is_corresponding | False |
| authorships[29].raw_affiliation_strings | Punjab Institute of Cardiology |
| authorships[30].author.id | https://openalex.org/A5102423164 |
| authorships[30].author.orcid | |
| authorships[30].author.display_name | Muhammad Hamid Saeed |
| authorships[30].countries | PK |
| authorships[30].affiliations[0].institution_ids | https://openalex.org/I4210147796 |
| authorships[30].affiliations[0].raw_affiliation_string | Faisalabad Institute of Cardiology |
| authorships[30].institutions[0].id | https://openalex.org/I4210147796 |
| authorships[30].institutions[0].ror | https://ror.org/04eps4h65 |
| authorships[30].institutions[0].type | education |
| authorships[30].institutions[0].lineage | https://openalex.org/I4210147796 |
| authorships[30].institutions[0].country_code | PK |
| authorships[30].institutions[0].display_name | University of Faisalabad |
| authorships[30].author_position | middle |
| authorships[30].raw_author_name | Muhammad Hamid Saeed |
| authorships[30].is_corresponding | False |
| authorships[30].raw_affiliation_strings | Faisalabad Institute of Cardiology |
| authorships[31].author.id | https://openalex.org/A5104014582 |
| authorships[31].author.orcid | |
| authorships[31].author.display_name | Shahid Abbas |
| authorships[31].countries | PK |
| authorships[31].affiliations[0].institution_ids | https://openalex.org/I4210147796 |
| authorships[31].affiliations[0].raw_affiliation_string | Faisalabad Institute of Cardiology |
| authorships[31].institutions[0].id | https://openalex.org/I4210147796 |
| authorships[31].institutions[0].ror | https://ror.org/04eps4h65 |
| authorships[31].institutions[0].type | education |
| authorships[31].institutions[0].lineage | https://openalex.org/I4210147796 |
| authorships[31].institutions[0].country_code | PK |
| authorships[31].institutions[0].display_name | University of Faisalabad |
| authorships[31].author_position | middle |
| authorships[31].raw_author_name | Shahid Abbas |
| authorships[31].is_corresponding | False |
| authorships[31].raw_affiliation_strings | Faisalabad Institute of Cardiology |
| authorships[32].author.id | https://openalex.org/A5003798509 |
| authorships[32].author.orcid | |
| authorships[32].author.display_name | Fazal Rehman Memon |
| authorships[32].countries | NG |
| authorships[32].affiliations[0].institution_ids | https://openalex.org/I172614708 |
| authorships[32].affiliations[0].raw_affiliation_string | Red Crescent Institute of Cardiology |
| authorships[32].institutions[0].id | https://openalex.org/I172614708 |
| authorships[32].institutions[0].ror | https://ror.org/00htzc939 |
| authorships[32].institutions[0].type | education |
| authorships[32].institutions[0].lineage | https://openalex.org/I172614708 |
| authorships[32].institutions[0].country_code | NG |
| authorships[32].institutions[0].display_name | Crescent University |
| authorships[32].author_position | middle |
| authorships[32].raw_author_name | Fazal Rehman Memon |
| authorships[32].is_corresponding | False |
| authorships[32].raw_affiliation_strings | Red Crescent Institute of Cardiology |
| authorships[33].author.id | https://openalex.org/A5024793111 |
| authorships[33].author.orcid | https://orcid.org/0000-0003-2230-0330 |
| authorships[33].author.display_name | Muhammad Ishaq |
| authorships[33].countries | PK |
| authorships[33].affiliations[0].institution_ids | https://openalex.org/I2801307192 |
| authorships[33].affiliations[0].raw_affiliation_string | Karachi Institute of Cardiology |
| authorships[33].institutions[0].id | https://openalex.org/I2801307192 |
| authorships[33].institutions[0].ror | https://ror.org/023grzj16 |
| authorships[33].institutions[0].type | healthcare |
| authorships[33].institutions[0].lineage | https://openalex.org/I2801307192 |
| authorships[33].institutions[0].country_code | PK |
| authorships[33].institutions[0].display_name | Karachi Institute of Heart Diseases |
| authorships[33].author_position | middle |
| authorships[33].raw_author_name | Muhammad Ishaq |
| authorships[33].is_corresponding | False |
| authorships[33].raw_affiliation_strings | Karachi Institute of Cardiology |
| authorships[34].author.id | https://openalex.org/A5087452645 |
| authorships[34].author.orcid | https://orcid.org/0000-0001-7137-0672 |
| authorships[34].author.display_name | John Dominy |
| authorships[34].countries | CN |
| authorships[34].affiliations[0].institution_ids | https://openalex.org/I4210091341 |
| authorships[34].affiliations[0].raw_affiliation_string | Biomedical Research at Novartis |
| authorships[34].institutions[0].id | https://openalex.org/I4210091341 |
| authorships[34].institutions[0].ror | https://ror.org/00fxgea47 |
| authorships[34].institutions[0].type | company |
| authorships[34].institutions[0].lineage | https://openalex.org/I1283582996, https://openalex.org/I4210091341 |
| authorships[34].institutions[0].country_code | CN |
| authorships[34].institutions[0].display_name | Novartis (China) |
| authorships[34].author_position | middle |
| authorships[34].raw_author_name | John E. Dominy |
| authorships[34].is_corresponding | False |
| authorships[34].raw_affiliation_strings | Biomedical Research at Novartis |
| authorships[35].author.id | https://openalex.org/A5027044353 |
| authorships[35].author.orcid | https://orcid.org/0000-0001-6193-020X |
| authorships[35].author.display_name | Danish Saleheen |
| authorships[35].countries | US |
| authorships[35].affiliations[0].institution_ids | https://openalex.org/I2799503643 |
| authorships[35].affiliations[0].raw_affiliation_string | Columbia University Irving Medical Center |
| authorships[35].institutions[0].id | https://openalex.org/I2799503643 |
| authorships[35].institutions[0].ror | https://ror.org/01esghr10 |
| authorships[35].institutions[0].type | healthcare |
| authorships[35].institutions[0].lineage | https://openalex.org/I2799503643 |
| authorships[35].institutions[0].country_code | US |
| authorships[35].institutions[0].display_name | Columbia University Irving Medical Center |
| authorships[35].author_position | last |
| authorships[35].raw_author_name | Danish Saleheen |
| authorships[35].is_corresponding | False |
| authorships[35].raw_affiliation_strings | Columbia University Irving Medical Center |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.medrxiv.org/content/medrxiv/early/2024/03/18/2024.03.14.24303793.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Identification and characterization of human GDF15 knockouts |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T13452 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2745 |
| primary_topic.subfield.display_name | Rheumatology |
| primary_topic.display_name | GDF15 and Related Biomarkers |
| related_works | https://openalex.org/W4386791676, https://openalex.org/W2918015724, https://openalex.org/W2258326608, https://openalex.org/W2089027985, https://openalex.org/W3107994849, https://openalex.org/W4391339303, https://openalex.org/W4392691676, https://openalex.org/W3031548383, https://openalex.org/W2378337402, https://openalex.org/W3113662134 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2024.03.14.24303793 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | https://www.medrxiv.org/content/medrxiv/early/2024/03/18/2024.03.14.24303793.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2024.03.14.24303793 |
| primary_location.id | doi:10.1101/2024.03.14.24303793 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | https://www.medrxiv.org/content/medrxiv/early/2024/03/18/2024.03.14.24303793.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2024.03.14.24303793 |
| publication_date | 2024-03-18 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2891822635, https://openalex.org/W4314935929, https://openalex.org/W4389670636, https://openalex.org/W2890397033, https://openalex.org/W2917530221, https://openalex.org/W4214517616, https://openalex.org/W2791984163, https://openalex.org/W2605659507, https://openalex.org/W1985885706, https://openalex.org/W4281934192, https://openalex.org/W4317941624, https://openalex.org/W2748135921, https://openalex.org/W2750180661, https://openalex.org/W2759628183, https://openalex.org/W1975913194, https://openalex.org/W2057219729, https://openalex.org/W1963540704, https://openalex.org/W1983011875, https://openalex.org/W3108271526, https://openalex.org/W4319346510, https://openalex.org/W3157404826, https://openalex.org/W4385851817, https://openalex.org/W3177160312, https://openalex.org/W3162800482, https://openalex.org/W2133520037 |
| referenced_works_count | 25 |
| abstract_inverted_index., | 45 |
| abstract_inverted_index.. | 23, 89, 114 |
| abstract_inverted_index.1 | 22 |
| abstract_inverted_index.2 | 44 |
| abstract_inverted_index.3 | 131 |
| abstract_inverted_index.5 | 98 |
| abstract_inverted_index.a | 7, 67 |
| abstract_inverted_index.15 | 4 |
| abstract_inverted_index.31 | 156 |
| abstract_inverted_index.59 | 135 |
| abstract_inverted_index.75 | 158 |
| abstract_inverted_index.97 | 124 |
| abstract_inverted_index.We | 115 |
| abstract_inverted_index.be | 191 |
| abstract_inverted_index.by | 145 |
| abstract_inverted_index.in | 19, 29, 36, 55, 71, 107, 140, 153 |
| abstract_inverted_index.is | 6, 52, 86, 178 |
| abstract_inverted_index.no | 164 |
| abstract_inverted_index.of | 27, 49, 79, 120, 147, 188 |
| abstract_inverted_index.or | 77, 203 |
| abstract_inverted_index.to | 58, 66, 157 |
| abstract_inverted_index.we | 91 |
| abstract_inverted_index.(i) | 174 |
| abstract_inverted_index.8,9 | 113 |
| abstract_inverted_index.LOF | 122 |
| abstract_inverted_index.The | 24 |
| abstract_inverted_index.age | 154 |
| abstract_inverted_index.and | 16, 46, 61, 127, 134, 162, 182, 193 |
| abstract_inverted_index.but | 74 |
| abstract_inverted_index.for | 69, 117 |
| abstract_inverted_index.may | 190, 197 |
| abstract_inverted_index.not | 198 |
| abstract_inverted_index.our | 170 |
| abstract_inverted_index.the | 47, 75, 108, 118 |
| abstract_inverted_index.(ii) | 184 |
| abstract_inverted_index.body | 14, 201 |
| abstract_inverted_index.data | 171 |
| abstract_inverted_index.food | 12 |
| abstract_inverted_index.from | 103, 155 |
| abstract_inverted_index.life | 181 |
| abstract_inverted_index.loss | 43, 177 |
| abstract_inverted_index.null | 100 |
| abstract_inverted_index.role | 68 |
| abstract_inverted_index.that | 10, 173 |
| abstract_inverted_index.were | 138, 160 |
| abstract_inverted_index.with | 123, 180 |
| abstract_inverted_index.(PGR) | 112 |
| abstract_inverted_index.(RBG) | 142 |
| abstract_inverted_index.(iii) | 194 |
| abstract_inverted_index.3–7 | 88 |
| abstract_inverted_index.GDF15 | 28, 34, 50, 70, 81, 93, 121, 150, 176, 189, 195 |
| abstract_inverted_index.Here, | 90 |
| abstract_inverted_index.Human | 63 |
| abstract_inverted_index.being | 53 |
| abstract_inverted_index.loss, | 82 |
| abstract_inverted_index.overt | 166 |
| abstract_inverted_index.point | 65 |
| abstract_inverted_index.treat | 59 |
| abstract_inverted_index.(LOF), | 96 |
| abstract_inverted_index.75,018 | 104 |
| abstract_inverted_index.Growth | 1 |
| abstract_inverted_index.binary | 128 |
| abstract_inverted_index.caused | 38 |
| abstract_inverted_index.during | 84 |
| abstract_inverted_index.effect | 48 |
| abstract_inverted_index.factor | 3 |
| abstract_inverted_index.family | 148 |
| abstract_inverted_index.humans | 30, 37 |
| abstract_inverted_index.impact | 78, 200 |
| abstract_inverted_index.models | 21 |
| abstract_inverted_index.nausea | 39 |
| abstract_inverted_index.ranged | 152 |
| abstract_inverted_index.safety | 76 |
| abstract_inverted_index.showed | 163 |
| abstract_inverted_index.stress | 17 |
| abstract_inverted_index.tested | 54, 116 |
| abstract_inverted_index.traits | 126 |
| abstract_inverted_index.trials | 57 |
| abstract_inverted_index.weight | 42, 202 |
| abstract_inverted_index.years, | 159 |
| abstract_inverted_index.(GDF15) | 5 |
| abstract_inverted_index.Genomic | 110 |
| abstract_inverted_index.agonism | 35 |
| abstract_inverted_index.chronic | 185 |
| abstract_inverted_index.intake, | 13 |
| abstract_inverted_index.protein | 9 |
| abstract_inverted_index.remains | 31 |
| abstract_inverted_index.studies | 143 |
| abstract_inverted_index.unknown | 87 |
| abstract_inverted_index.weight, | 15 |
| abstract_inverted_index.without | 40 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Further, | 130 |
| abstract_inverted_index.Pakistan | 109 |
| abstract_inverted_index.Resource | 111 |
| abstract_inverted_index.cachexia | 60 |
| abstract_inverted_index.carriers | 95, 101, 137 |
| abstract_inverted_index.clinical | 56 |
| abstract_inverted_index.complete | 80, 175 |
| abstract_inverted_index.enrolled | 106 |
| abstract_inverted_index.fertile, | 161 |
| abstract_inverted_index.function | 26 |
| abstract_inverted_index.genetics | 64 |
| abstract_inverted_index.indicate | 172 |
| abstract_inverted_index.members. | 149 |
| abstract_inverted_index.secreted | 8 |
| abstract_inverted_index.unclear. | 32 |
| abstract_inverted_index.anorexia. | 62 |
| abstract_inverted_index.including | 97 |
| abstract_inverted_index.knockouts | 133, 151 |
| abstract_inverted_index.metabolic | 167, 204 |
| abstract_inverted_index.outcomes. | 129 |
| abstract_inverted_index.regulates | 11 |
| abstract_inverted_index.responses | 18 |
| abstract_inverted_index.syndrome. | 205 |
| abstract_inverted_index.additional | 132 |
| abstract_inverted_index.antagonism | 51 |
| abstract_inverted_index.compatible | 179 |
| abstract_inverted_index.consistent | 165 |
| abstract_inverted_index.fertility, | 183 |
| abstract_inverted_index.homozygous | 99 |
| abstract_inverted_index.identified | 139 |
| abstract_inverted_index.inhibition | 187 |
| abstract_inverted_index.modulation | 196 |
| abstract_inverted_index.pregnancy, | 85 |
| abstract_inverted_index.tolerated, | 192 |
| abstract_inverted_index.accompanied | 144 |
| abstract_inverted_index.association | 119 |
| abstract_inverted_index.gravidarum, | 73 |
| abstract_inverted_index.hyperemesis | 72 |
| abstract_inverted_index.recruitment | 146 |
| abstract_inverted_index.therapeutic | 186 |
| abstract_inverted_index.accompanying | 41 |
| abstract_inverted_index.characterize | 92 |
| abstract_inverted_index.dysfunction. | 168 |
| abstract_inverted_index.heterozygous | 136 |
| abstract_inverted_index.participants | 105 |
| abstract_inverted_index.particularly | 83 |
| abstract_inverted_index.pre-clinical | 20 |
| abstract_inverted_index.quantitative | 125 |
| abstract_inverted_index.Collectively, | 169 |
| abstract_inverted_index.physiological | 25 |
| abstract_inverted_index.significantly | 199 |
| abstract_inverted_index.differentiation | 2 |
| abstract_inverted_index.loss-of-function | 94 |
| abstract_inverted_index.(“knockouts”) | 102 |
| abstract_inverted_index.Pharmacologically, | 33 |
| abstract_inverted_index.recall-by-genotype | 141 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| countries_distinct_count | 5 |
| institutions_distinct_count | 36 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.5400000214576721 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.77628855 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |