Identification of claudin-3 as an entry factor for rat hepacivirus Article Swipe
Tomohisa Tanaka
,
Yasunori Akaike
,
Hirotake Kasai
,
Atsuya Yamashita
,
Yoshiharu Matsuura
,
Kohji Moriishi
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2508736122
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2508736122
Approximately 58 million people worldwide are believed to be infected with hepatitis C virus (HCV), a major causative agent of chronic liver diseases. Hepacivirus ratti strain rn-1, which was discovered from Rattus norvegicus (Norway rat) and designated Norway rat hepacivirus 1 (NRHV1), shares similar properties with HCV in terms of genetic homology, target cell tropism, pathogenicity, and the immune response. In vivo infection systems for NRHV1 will help overcome the challenges in HCV research for vaccine development. However, the virological characteristics of NRHV1, such as the mechanisms of cell entry, remain largely unexplored, in part owing to a paucity of cell culture systems for NRHV1. Here, we identified the host factors that facilitate NRHV1 entry by profiling the gene expression of two cell lines with different susceptibilities to NRHV1 infection. NRHV1 employs rodent orthologues of HCV entry factors, including scavenger receptor class BI, CD81, and occludin, and utilizes claudin-3 (CLDN3) but not claudin-1. The expression of rat and mouse, but not human, CLDN3 facilitates the entry of NRHV1 into murine cell lines that are nonsusceptible to NRHV1 infection. The host-specific cell entry of CLDN3 is determined by two amino acid residues, Ile 44 and Trp 46 , in extracellular loop 1. These findings suggest that CLDN3 serves as an entry factor for rat hepacivirus.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.2508736122
- https://www.pnas.org/doi/pdf/10.1073/pnas.2508736122
- OA Status
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- Cited By
- 1
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- 51
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4414758853Canonical identifier for this work in OpenAlex
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https://doi.org/10.1073/pnas.2508736122Digital Object Identifier
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Identification of claudin-3 as an entry factor for rat hepacivirusWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
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2025Year of publication
- Publication date
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2025-10-02Full publication date if available
- Authors
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Tomohisa Tanaka, Yasunori Akaike, Hirotake Kasai, Atsuya Yamashita, Yoshiharu Matsuura, Kohji MoriishiList of authors in order
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https://doi.org/10.1073/pnas.2508736122Publisher landing page
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https://www.pnas.org/doi/pdf/10.1073/pnas.2508736122Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://www.pnas.org/doi/pdf/10.1073/pnas.2508736122Direct OA link when available
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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51Number of works referenced by this work
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