Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile Article Swipe
Jeremy R. Duvall
,
Leanne L. Bedard
,
Adel M. Naylor-Olsen
,
Abigail L. Manson
,
Joshua A. Bittker
,
Wenye Sun
,
Mark E. Fitzgerald
,
Zhenmin He
,
Maurice D. Lee
,
Jean‐Charles Marié
,
Giovanni Muncipinto
,
Diane M. Rush
,
Deming Xu
,
Huisheng Xu
,
Mingliang Zhang
,
Ashlee M. Earl
,
Michelle Palmer
,
Michael A. Foley
,
Joseph P. Vacca
,
Christina Scherer
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1021/acsinfecdis.6b00206
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1021/acsinfecdis.6b00206
In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options currently exist, many of which result in disease relapse. We sought to identify molecules specifically targeting C. difficile in high-throughput screens of our diversity-oriented synthesis compound collection. We identified two scaffolds with apparently novel mechanisms of action that selectively target C. difficile while having little to no activity against other intestinal anaerobes; preliminary evidence suggests that compounds from one of these scaffolds target the glutamate racemase. In vivo efficacy data suggest that both compound series may provide lead optimization candidates.
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Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acsinfecdis.6b00206
- OA Status
- green
- Cited By
- 16
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2588703681
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2588703681Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1021/acsinfecdis.6b00206Digital Object Identifier
- Title
-
Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficileWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-02-19Full publication date if available
- Authors
-
Jeremy R. Duvall, Leanne L. Bedard, Adel M. Naylor-Olsen, Abigail L. Manson, Joshua A. Bittker, Wenye Sun, Mark E. Fitzgerald, Zhenmin He, Maurice D. Lee, Jean‐Charles Marié, Giovanni Muncipinto, Diane M. Rush, Deming Xu, Huisheng Xu, Mingliang Zhang, Ashlee M. Earl, Michelle Palmer, Michael A. Foley, Joseph P. Vacca, Christina SchererList of authors in order
- Landing page
-
https://doi.org/10.1021/acsinfecdis.6b00206Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1021/acsinfecdis.6b00206Direct OA link when available
- Concepts
-
Clostridium difficile, C difficile, Antibiotics, Virulence, Microbiology, Identification (biology), Biology, In vivo, Computational biology, Gene, Genetics, BotanyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
16Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2023: 1, 2022: 4, 2021: 2, 2019: 2Per-year citation counts (last 5 years)
- References (count)
-
33Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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