Identification of HIV-Transmitting Sub-Epithelial Mononuclear Phagocytes in Human Anogenital and Colorectal Tissues Article Swipe
Jake W. Rhodes
,
Rachel A. Botting
,
Kirstie M. Bertram
,
Hafsa Rana
,
Heeva Baharlou
,
Erica E Longmuir-Vine
,
Péter Végh
,
James L. K. Fletcher
,
Thomas R. O’Neil
,
Grant P. Parnell
,
J. Dinny Graham
,
Najla Nasr
,
Jake Lim
,
Laith Barnouti
,
Peter Haertsch
,
M. Gosselink
,
Angelina Di Re
,
Grahame Ctercteko
,
Gregory J. Jenkins
,
Andrew J. Brooks
,
Ellis Patrick
,
Scott N. Byrne
,
Muzlifah Haniffa
,
Anthony L. Cunningham
,
Andrew N. Harman
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.05.26.117408
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.05.26.117408
Tissue mononuclear phagocytes (MNP) are specialised in pathogen detection and antigen presentation. They are the first cells of the immune system to encounter HIV and play a key role in transmission as they deliver the virus to CD4 T cells, which are the primary HIV target cell in which the virus undergoes replication. Most studies have investigated the role that epithelial MNPs play in HIV transmission but, as mucosal trauma and inflammation are strongly associated with HIV transmission, it is also important to examine the role that sub-epithelial MNPs play. Sub-epithelial MNPs are present in a diverse array of subsets which differ in their function and the pathogens they detect. Understanding how specific subsets interact with HIV and deliver the virus to CD4 T cells is therefore of key importance to vaccine and microbicide development. In this study we have shown that, after topical application, HIV can penetrate to interact with sub-epithelial resident myeloid cells in anogenital explants and defined the full array of MNP subsets that are present in all the human anogenital and colorectal sub-epithelial tissues that HIV may encounter during sexual transmission. In doing so we have identified two subsets that preferentially take up HIV, become infected and transmit the virus to CD4 T cells; CD14 + CD1c + CD11c + monocyte-derived dendritic cells and langerin-expressing dendritic cells 2 (DC2).
Related Topics
Concepts
Langerin
CD11c
CD14
Biology
Immunology
Sexual transmission
Dendritic cell
Immune system
Virology
Virus
Human immunodeficiency virus (HIV)
Microbicide
Gene
Biochemistry
Phenotype
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.05.26.117408
- https://www.biorxiv.org/content/biorxiv/early/2020/05/29/2020.05.26.117408.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 68
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3030251694
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3030251694Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2020.05.26.117408Digital Object Identifier
- Title
-
Identification of HIV-Transmitting Sub-Epithelial Mononuclear Phagocytes in Human Anogenital and Colorectal TissuesWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-05-29Full publication date if available
- Authors
-
Jake W. Rhodes, Rachel A. Botting, Kirstie M. Bertram, Hafsa Rana, Heeva Baharlou, Erica E Longmuir-Vine, Péter Végh, James L. K. Fletcher, Thomas R. O’Neil, Grant P. Parnell, J. Dinny Graham, Najla Nasr, Jake Lim, Laith Barnouti, Peter Haertsch, M. Gosselink, Angelina Di Re, Grahame Ctercteko, Gregory J. Jenkins, Andrew J. Brooks, Ellis Patrick, Scott N. Byrne, Muzlifah Haniffa, Anthony L. Cunningham, Andrew N. HarmanList of authors in order
- Landing page
-
https://doi.org/10.1101/2020.05.26.117408Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2020/05/29/2020.05.26.117408.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2020/05/29/2020.05.26.117408.full.pdfDirect OA link when available
- Concepts
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Langerin, CD11c, CD14, Biology, Immunology, Sexual transmission, Dendritic cell, Immune system, Virology, Virus, Human immunodeficiency virus (HIV), Microbicide, Gene, Biochemistry, PhenotypeTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2021: 1Per-year citation counts (last 5 years)
- References (count)
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68Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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