Virulence • Vol 14 • No 1
Identification of <i>Staphylococcus aureus</i> virulence-modulating RNA from transcriptomics data with machine learning
July 2023 • Jinlong Yu, Mingzhang Li, Jin Wang, Musha Hamushan, Feng Jiang, Boyong Wang, Yujie Hu, Pei Han, Jin Tang, Geyong Guo, Hao Shen
The virulence factors of <i>Staphylococcus aureus</i> are tightly controlled by two-component systems (TCSs) and small RNA (sRNA). TCSs have been well studied over the past several decades, but our understanding of sRNA functions lags far behind that of TCS functions. Here, we studied the biological role of sRNA from 506 <i>S. aureus</i> RNA-seq datasets using independent component analysis (ICA). We found that a previously neglected sRNA, Sau-41, functions in the Agr system. Sau-41 is located within the PSMα oper…