Identification of lysophosphatidylthreonine with an aromatic fatty acid surrogate as a potent inducer of mast cell degranulation Article Swipe
Takayuki Kishi
,
Hiroki Kawana
,
Misa Sayama
,
Kumiko Makide
,
Asuka Inoue
,
Yuko Otani
,
Tomohiko Ohwada
,
Junken Aoki
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1016/j.bbrep.2016.09.013
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1016/j.bbrep.2016.09.013
Upon various stimulations, mast cells (MCs) release a wide variety of chemical mediators stored in their cytoplasmic granules, which then initiates subsequent allergic reactions. Lysophosphatidylserine (LysoPS), a kind of lysophospholipid, potentiates the histamine release from MCs triggered by antigen stimulation. We previously showed through structure-activity studies of LysoPS analogs that LysoPS with a methyl group at the carbon of the serine residue, i.e., lysophosphatidylthreonine (LysoPT), is extremely potent in stimulating the MC degranulation. In this study, as our continuing study to identify more potent LysoPS analogs, we developed LysoPS analogs with fatty acid surrogates. We found that the substitution of oleic acid to an aromatic fatty acid surrogate (C3-pH-p-O-C11) in 2-deoxy-1-LysoPS resulted in significant increase in the ability to induce MCs degranulation compared with 2-deoxy-1-LysoPS with oleic acid. Conversion of the serine residue into the threonine residue further increased the activity of MC degranulation both in vitro and in vivo. The resulting super agonist, 2-deoxy-LysoPT with C3-pH-p-O-C11, will be a useful tool to elucidate the mechanisms of stimulatory effect of LysoPS on MC degranulation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.bbrep.2016.09.013
- OA Status
- gold
- Cited By
- 5
- References
- 14
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2530697306
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2530697306Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.bbrep.2016.09.013Digital Object Identifier
- Title
-
Identification of lysophosphatidylthreonine with an aromatic fatty acid surrogate as a potent inducer of mast cell degranulationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2016Year of publication
- Publication date
-
2016-10-11Full publication date if available
- Authors
-
Takayuki Kishi, Hiroki Kawana, Misa Sayama, Kumiko Makide, Asuka Inoue, Yuko Otani, Tomohiko Ohwada, Junken AokiList of authors in order
- Landing page
-
https://doi.org/10.1016/j.bbrep.2016.09.013Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.bbrep.2016.09.013Direct OA link when available
- Concepts
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Degranulation, Chemistry, Mast cell, Histamine, Biochemistry, Serine, Compound 48/80, Fatty acid, Oleic acid, Residue (chemistry), In vivo, Pharmacology, Enzyme, Biology, Immunology, Receptor, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2021: 1, 2020: 2, 2017: 1Per-year citation counts (last 5 years)
- References (count)
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14Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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