Identification of unique proteins in vitreous fluid of patients with noninfectious uveitis Article Swipe
Kripa Shanker Kasudhan
,
Subendu Sarkar
,
Vishali Gupta
,
Amod Gupta
,
Anuradha Chakraborti
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1111/aos.13801
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1111/aos.13801
Purpose Uveitis is a cause for concern in the developing countries like India. Its poor diagnosis and lack of proper therapeutics often cause blindness in children and young adults. Moreover, the exact mechanism of pathogenesis of different types of uveitis is still elusive. Modern proteomic techniques are found to be advantageous for an in‐depth understanding of the ocular physiology using proteomic diversity. Our aim was to identify unique proteins involved in the pathogenesis of autoimmune or noninfectious uveitis. Methods Vitreous fluid samples ( n = 90) were obtained from infectious ( N = 34) and noninfectious ( N = 56) uveitis patients, and their protein profiles were compared by analysing sodium dodecyl sulphate–polyacrylamide gel electrophoresis (SDS‐PAGE) and 2D electrophoresis. Unique proteins were identified through matrix‐assisted laser desorption ionization–time‐of‐flight mass spectrometry (MALDI‐TOF MS) and further studied for pathway analysis. Results Protein spots having different molecular weights were observed in noninfectious vitreous fluid samples. Enzymatic digestion of these spots after MALDI‐TOF MS analysis revealed different proteins. We identified 25 different proteins through SDS‐PAGE and 22 through 2D electrophoresis. 50% of the proteins from SDS‐PAGE were associated with heterotrimeric G‐protein signalling pathway–rod outer segment phototransduction. 50% proteins from SDS‐PAGE and 20% from 2D electrophoresis revealed association with de novo purine biosynthesis. Carbonic anhydrase 1 and serpin B3 were found to be common in both analyses. Conclusion High‐throughput proteomic and pathway analyses have exposed the potential association of these proteins with autoimmune pathogenesis in uveitis. The exact role of most of the proteins in autoimmune uveitis is yet to be unfurled.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/aos.13801
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/aos.13801
- OA Status
- bronze
- Cited By
- 12
- References
- 79
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2889349588
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2889349588Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/aos.13801Digital Object Identifier
- Title
-
Identification of unique proteins in vitreous fluid of patients with noninfectious uveitisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-08-26Full publication date if available
- Authors
-
Kripa Shanker Kasudhan, Subendu Sarkar, Vishali Gupta, Amod Gupta, Anuradha ChakrabortiList of authors in order
- Landing page
-
https://doi.org/10.1111/aos.13801Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/aos.13801Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/aos.13801Direct OA link when available
- Concepts
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Pathogenesis, Proteome, Uveitis, Proteomics, Gel electrophoresis, Polyacrylamide gel electrophoresis, Medicine, Chemistry, Molecular biology, Biology, Biochemistry, Immunology, Enzyme, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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12Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1, 2023: 2, 2022: 1, 2021: 2, 2020: 1Per-year citation counts (last 5 years)
- References (count)
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79Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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