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Identifying causal serum protein–cardiometabolic trait relationships using whole genome sequencing
November 2022 • Grace Png, Raffaele Gerlini, Konstantinos Hatzikotoulas, Andrei Barysenka, Nigel W. Rayner, Lucija Klarić, Birgit Rathkolb, Juan Antonio Aguilar‐Pime…
Abstract Cardiometabolic diseases, such as type 2 diabetes and cardiovascular disease, have a high public health burden. Understanding the genetically determined regulation of proteins that are dysregulated in disease can help to dissect the complex biology underpinning them. Here, we perform a protein quantitative trait locus (pQTL) analysis of 248 serum proteins relevant to cardiometabolic processes in 2893 individuals. Meta-analyzing whole-genome sequencing (WGS) data from two Greek cohorts, MANOLIS (n = 1356; …
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