Identifying crosstalks among post-translational modifications in lung cancer proteomic data Article Swipe
Shengzhi Lai
,
Shuaijian Dai
,
Peize Zhao
,
Chen Zhou
,
Ning Li
,
Weichuan Yu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.06.606765
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.06.606765
In a lung squamous cell carcinoma data set containing over 20 million tandem mass spectra, we identified 860 peptides with post-translational modifications (PTMs) that were significantly upregulated in lung cancer samples as compared to normal samples using our new search engine named PIPI3. Among the modified peptides related to upregulated gene ontology terms, about 50% carried multiple PTMs. PIPI3 demonstrated its enabling power to provide insight into PTM crosstalk research.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.08.06.606765
- https://www.biorxiv.org/content/biorxiv/early/2024/08/08/2024.08.06.606765.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401414806
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401414806Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2024.08.06.606765Digital Object Identifier
- Title
-
Identifying crosstalks among post-translational modifications in lung cancer proteomic dataWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-08-08Full publication date if available
- Authors
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Shengzhi Lai, Shuaijian Dai, Peize Zhao, Chen Zhou, Ning Li, Weichuan YuList of authors in order
- Landing page
-
https://doi.org/10.1101/2024.08.06.606765Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2024/08/08/2024.08.06.606765.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2024/08/08/2024.08.06.606765.full.pdfDirect OA link when available
- Concepts
-
Downregulation and upregulation, Crosstalk, Lung cancer, Computational biology, Cancer research, Chemistry, Biology, Gene, Medicine, Biochemistry, Oncology, Engineering, Electronic engineeringTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
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25Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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