Ficus Carica L. Latex: Possible Chemo-Preventive, Apoptotic Activity and Safety Assessment. Article Swipe

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Fereshteh Jeivad , Nargues Yassa , Seyed Nasser Ostad , Zahra Hassannejad , Gholamreza Hassanzadeh Gheshlaghi , Omid Sabzevari ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.22037/ijpr.2020.1101151

Hepatocellular carcinoma is the third cause of cancer-related mortality with the low 5-year survival in which more than 50 percent of patients have recurrent cancer within 2 years of treatment. The present study investigated the cytotoxicity and lethal dose of Ficus carica L. (Figure) latex and phytochemical composition of effective fraction. Figure latex was collected in summer and 4 fractions of Figure latex were prepared. The cytotoxic effect of each fraction was studied and the most effective fraction was selected for apoptosis assay, acute toxicity study, and phytochemical analysis using column chromatography. The isolated compounds were identified by ¹H-NMR, ¹³C-NMR, and mass spectroscopy. Chloroform fraction was the most effective fraction with the IC₅₀ value of 0.219 and 0.748 mg/mL for HepG2 and NIH cell lines, respectively. Presence of cells in early apoptotic phase was documented by flow cytometry assay. Single dose administration of 2g/kg of fraction did not cause any death. Phytochemical analyses confirmed presence of lupeol acetate and lupeol palmitate in chloroform fraction. The present study revealed that the chloroform fraction is not only 3.4 times more toxic in HepG2 cell line but also has low in-vivo toxicity which could be considered as a good candidate for a chemo-preventive agent.

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Phytochemical Lupeol Carica Traditional medicine Acute toxicity Chloroform Fraction (chemistry) Toxicity Chemistry Chromatography Cytotoxicity Median lethal dose Apoptosis Pharmacology Medicine In vitro Biology Biochemistry Botany Organic chemistry

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Type: article
Language: en
Landing Page: https://pubmed.ncbi.nlm.nih.gov/33680025
OA Status: green
Cited By: 8
References: 3
OpenAlex ID: https://openalex.org/W3120282218

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OpenAlex ID: https://openalex.org/W3120282218

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DOI: https://doi.org/10.22037/ijpr.2020.1101151

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Title: Ficus Carica L. Latex: Possible Chemo-Preventive, Apoptotic Activity and Safety Assessment.

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Language: en

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Publication year: 2020

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Publication date: 2020-01-01

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Authors: Fereshteh Jeivad, Nargues Yassa, Seyed Nasser Ostad, Zahra Hassannejad, Gholamreza Hassanzadeh Gheshlaghi, Omid Sabzevari

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Landing page: https://pubmed.ncbi.nlm.nih.gov/33680025

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Concepts: Phytochemical, Lupeol, Carica, Traditional medicine, Acute toxicity, Chloroform, Fraction (chemistry), Toxicity, Chemistry, Chromatography, Cytotoxicity, Median lethal dose, Apoptosis, Pharmacology, Medicine, In vitro, Biology, Biochemistry, Botany, Organic chemistry

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Cited by: 8

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Citations by year (recent): 2024: 2, 2023: 2, 2022: 3, 2021: 1

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