IgG replacement in multiple myeloma Article Swipe
Alex Wonnaparhown
,
Talal Hilal
,
Jacqueline D. Squire
,
Catherine Freeman
,
Rafaël Fonseca
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41408-024-01107-6
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41408-024-01107-6
T cell engagers (TCE) such as chimeric antigen receptor (CAR) T cell therapy and bispecific antibodies (BiAbs) for the treatment of multiple myeloma (MM) have significantly improved clinical outcomes, but have also raised awareness for ensuing post-treatment secondary immunodeficiency and hypogammaglobulinemia (HG). As patients with MM live longer, recurrent infections become a significant component of therapy-associated morbidity and mortality. Treatment of HG with immunoglobulin G replacement therapy (IgG-RT) has been a mainstay of the primary immunodeficiency (PI) world, and extrapolation to MM has recently started to show promising clinical outcomes. However, IgG-RT initiation, dosing, route, timing, monitoring, and management in MM has not been standardized in the setting of TCE. Progress in MM treatment will involve greater recognition and screening of underlying secondary immunodeficiency, identification of risk-stratification markers, optimizing IgG-RT management, and implementing other approaches to decrease the risk of infection. In this review, we summarize infection risk, risk of HG, and management strategies for IgG-RT in patients with relapsed MM after TCE.
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Metadata
- Type
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- https://doi.org/10.1038/s41408-024-01107-6
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- gold
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- 11
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All OpenAlex metadata
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https://openalex.org/W4400985162Canonical identifier for this work in OpenAlex
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https://doi.org/10.1038/s41408-024-01107-6Digital Object Identifier
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IgG replacement in multiple myelomaWork title
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reviewOpenAlex work type
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enPrimary language
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2024Year of publication
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2024-07-25Full publication date if available
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Alex Wonnaparhown, Talal Hilal, Jacqueline D. Squire, Catherine Freeman, Rafaël FonsecaList of authors in order
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https://doi.org/10.1038/s41408-024-01107-6Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1038/s41408-024-01107-6Direct OA link when available
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Multiple myeloma, Medicine, Internal medicine, Hematology, Oncology, ImmunologyTop concepts (fields/topics) attached by OpenAlex
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11Total citation count in OpenAlex
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2025: 6, 2024: 5Per-year citation counts (last 5 years)
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68Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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