Hermetia illucens-Derived Chitosan: A Promising Immunomodulatory Agent for Applications in Biomedical Fields Article Swipe
Alessandra Fusco
,
Anna Guarnieri
,
Carmen Scieuzo
,
Micaela Triunfo
,
Rosanna Salvia
,
Giovanna Donnarumma
,
Patrizia Falabella
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acs.biomac.5c00362
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acs.biomac.5c00362
Chitosan, renowned for its important biological properties, is a valuable pharmaceutical excipient for different therapeutic approaches. Currently, the demand for the biopolymer on the market is growing, and, for this reason, it is important to biologically characterize the biopolymer produced from an alternative source to crustaceans, specifically the bioconverter insect Hermetia illucens. In this work, insect chitosan, yielded via heterogeneous and homogeneous deacetylation from larvae, pupal exuviae, and adults, was studied as an immunomodulatory agent. The inflammatory response of immortalized human keratinocyte cells was induced by Salmonella enterica subsp. enterica serovar Typhimurium lipopolysaccharide. After that, the ability of the biopolymer to reduce the expression of the pro-inflammatory cytokines IL-6, IL-8, IL-1α, and TNF-α was tested after 6 and 24 h of treatment. Insect chitosan samples effectively downregulated cytokine expression, with improved activity obtained from heterogeneous chitosan treatments.
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Metadata
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- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acs.biomac.5c00362
- OA Status
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- Cited By
- 2
- References
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4409911040Canonical identifier for this work in OpenAlex
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https://doi.org/10.1021/acs.biomac.5c00362Digital Object Identifier
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Hermetia illucens-Derived Chitosan: A Promising Immunomodulatory Agent for Applications in Biomedical FieldsWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-04-29Full publication date if available
- Authors
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Alessandra Fusco, Anna Guarnieri, Carmen Scieuzo, Micaela Triunfo, Rosanna Salvia, Giovanna Donnarumma, Patrizia FalabellaList of authors in order
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https://doi.org/10.1021/acs.biomac.5c00362Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1021/acs.biomac.5c00362Direct OA link when available
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Hermetia illucens, Chitosan, Chemistry, Nanotechnology, Materials science, Organic chemistry, Biology, Ecology, LarvaTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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