In vitro and in vivo assessment of biomedical Mg–Ca alloys for bone implant applications Article Swipe
Preeti Makkar
,
Swapan Kumar Sarkar
,
Andrew Padalhin
,
Byoung-Gi Moon
,
Young Seon Lee
,
Byong‐Taek Lee
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1177/2280800017750359
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1177/2280800017750359
Background: Magnesium (Mg)-based alloys are considered to be promising materials for implant application due to their excellent biocompatibility, biodegradability, and mechanical properties close to bone. However, low corrosion resistance and fast degradation are limiting their application. Mg–Ca alloys have huge potential owing to a similar density to bone, good corrosion resistance, and as Mg is essential for Ca incorporation into bone. The objective of the present work is to determine the in vitro degradation and in vivo performance of binary Mg– xCa alloy ( x = 0.5 or 5.0 wt%) to assess its usability for degradable implant applications. Methods: Microstructural evolutions for Mg– xCa alloys were characterized by optical, SEM, EDX, and XRD. In vitro degradation tests were conducted via immersion test in phosphate buffer saline solution. In vivo performance in terms of interface, biocompatibility, and biodegradability of Mg– xCa alloys was examined by implanting samples into rabbit femoral condyle for 2 and 4 weeks. Results: Microstructural results showed the enhancement in intermetallic Mg 2 Ca phase with increase in Ca content. Immersion tests revealed that the dissolution rate varies linearly, with Ca content exhibiting more hydrogen gas evolution, increased pH, and higher degradation for Mg–5.0Ca alloy. In vivo studies showed good biocompatibility with enhanced bone formation for Mg–0.5Ca after 4 weeks of implantation compared with Mg–5.0Ca alloy. Higher initial corrosion rate with prolonged inflammation and rapid degradation was noticed in Mg–5.0Ca compared with Mg–0.5Ca alloy. Conclusions: The results suggest that Mg–0.5Ca alloy could be used as a temporary biodegradable implant material for clinical applications owing to its controlled in vivo degradation, reduced inflammation, and high bone-formation capability.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/2280800017750359
- https://journals.sagepub.com/doi/pdf/10.1177/2280800017750359
- OA Status
- bronze
- Cited By
- 68
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2802356449
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2802356449Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/2280800017750359Digital Object Identifier
- Title
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In vitro and in vivo assessment of biomedical Mg–Ca alloys for bone implant applicationsWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2018Year of publication
- Publication date
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2018-04-02Full publication date if available
- Authors
-
Preeti Makkar, Swapan Kumar Sarkar, Andrew Padalhin, Byoung-Gi Moon, Young Seon Lee, Byong‐Taek LeeList of authors in order
- Landing page
-
https://doi.org/10.1177/2280800017750359Publisher landing page
- PDF URL
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https://journals.sagepub.com/doi/pdf/10.1177/2280800017750359Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://journals.sagepub.com/doi/pdf/10.1177/2280800017750359Direct OA link when available
- Concepts
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Biocompatibility, Corrosion, Materials science, Alloy, In vivo, Nuclear chemistry, Implant, Intermetallic, Dissolution, Metallurgy, Biomedical engineering, Chemical engineering, Chemistry, Surgery, Medicine, Biotechnology, Biology, EngineeringTop concepts (fields/topics) attached by OpenAlex
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68Total citation count in OpenAlex
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2025: 6, 2024: 4, 2023: 14, 2022: 15, 2021: 10Per-year citation counts (last 5 years)
- References (count)
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26Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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