In Vitro and In Vivo Toxicity Studies on Cymbopogon giganteus Chiov. Leaves Essential Oil from Benin Article Swipe
Habib Toukourou
,
Francine Uwambayinema
,
Yousof Yakoub
,
Birgit Mertens
,
Anatóle Laleye
,
Dominique Lison
,
Joëlle Quetin‐Leclercq
,
Fernand Gbaguidi
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1155/2020/8261058
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1155/2020/8261058
Cymbopogon giganteus Chiov. (Poaceae) is a medicinal plant used to treat various diseases in traditional medicine in several African countries. The present study aims to evaluate the oral and inhalation toxicity as well as the mutagenic effects of the essential oil of Cymbopogon giganteus leaves (EOCG) from a sample collected in Benin. Mutagenic potential was assessed by the Ames test using Salmonella typhimurium strains TA98 and TA100. Oral acute toxicity was carried out by administration of a single dose of 2000 mg/kg b.w. to Wistar rats while oral subacute toxicity was assessed by daily administration of 50 and 500 mg/kg of EOCG for 28 days. Finally, inhalation toxicity was assessed by administration of a single dose of 0.125%, 0.5%, 2% or 5% v/v of EOCG emulsions in 0.05% v/v lecithin solution in sterile water for the first experiment, and in a second one by administration of single dose of 0.125% or 0.5% v/v. A broncho-alveolar lavage was performed after 3 h or 24 h, respectively. The results show that EOCG is not mutagenic on Salmonella typhimurium strains at the highest concentration tested (200 μ g/plate). In the acute oral toxicity study, EOCG induce neither mortality nor toxicity, showing that the LD 50 is greater than 2000 mg/kg. The subacute oral toxicity study at both doses did not show any significant difference in body weight, relative organ weight, hematological and/or biochemical parameters or histopathology as compared to the control group. EOCG induced mortality and inflammation in lungs 3 h after administration of a single dose of 5% or 2% v/v. Single doses of 0.125% or 0.5% v/v did not induce inflammation, cell recruitment nor cytotoxicity in lungs 3 h or 24 h after administration, suggesting safety at these concentrations. This first report on the in vivo toxicity will be useful to guide safe uses of EOCG.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1155/2020/8261058
- https://downloads.hindawi.com/journals/jt/2020/8261058.pdf
- OA Status
- gold
- Cited By
- 10
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3004255169
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3004255169Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1155/2020/8261058Digital Object Identifier
- Title
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In Vitro and In Vivo Toxicity Studies on Cymbopogon giganteus Chiov. Leaves Essential Oil from BeninWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-28Full publication date if available
- Authors
-
Habib Toukourou, Francine Uwambayinema, Yousof Yakoub, Birgit Mertens, Anatóle Laleye, Dominique Lison, Joëlle Quetin‐Leclercq, Fernand GbaguidiList of authors in order
- Landing page
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https://doi.org/10.1155/2020/8261058Publisher landing page
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https://downloads.hindawi.com/journals/jt/2020/8261058.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://downloads.hindawi.com/journals/jt/2020/8261058.pdfDirect OA link when available
- Concepts
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Toxicity, Acute toxicity, Oral administration, Traditional medicine, Biology, Essential oil, Toxicology, Medicine, Pharmacology, Botany, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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10Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 1, 2022: 4, 2021: 2Per-year citation counts (last 5 years)
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30Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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