In vitro resensitization of multidrug-resistant clinical isolates of Enterococcus faecium and E. faecalis through phage-antibiotic synergy Article Swipe
Pooja Ghatbale
,
Govind Prasad Sah
,
Sage J. B. Dunham
,
Ethan Khong
,
Alisha N. Blanc
,
Alisha N. Monsibais
,
Andrew Garcia
,
Robert T. Schooley
,
Ana G. Cobián-Güemes
,
Katrine Whiteson
,
David T. Pride
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1128/aac.00740-24
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1128/aac.00740-24
Bacteriophages are an increasingly attractive option for the treatment of antibiotic-resistant infections, but their efficacy is difficult to discern due to the confounding effects of antibiotics. Phages are generally delivered in conjunction with antibiotics, and thus, when patients improve, it is unclear whether the phages, antibiotics, or both are responsible. This question is particularly relevant for enterococcus infections, as limited data suggest phages might restore antibiotic efficacy against resistant strains. Enterococci can develop high-level resistance to vancomycin, a primary treatment. We assessed clinical and laboratory isolates of Enterococcus faecium and Enterococcus faecalis to determine whether we could observe synergistic interactions between phages and antibiotics. We identified synergy between multiple phages and antibiotics including linezolid, ampicillin, and vancomycin. Notably, antibiotic susceptibility did not predict synergistic interactions with phages. Vancomycin-resistant isolates ( n = 6) were eradicated by the vancomycin-phage combination as effectively as vancomycin-susceptible isolates ( n = 2). Transcriptome analysis revealed significant gene expression changes under antibiotic-phage conditions, especially for linezolid and vancomycin, with upregulated genes involved in nucleotide and protein biosynthesis and downregulated stress response and prophage-related genes. While our results do not conclusively determine the mechanism of the observed synergistic interactions between antibiotics and phages, they do confirm and build upon previous research that observed these synergistic interactions. Our work highlights how using phages can restore the effectiveness of vancomycin against resistant isolates. This finding provides a promising, although unexpected, strategy for moving forward with phage treatments for vancomycin-resistant Enterococcus infections.
Related Topics
Concepts
Antibiotics
Microbiology
Linezolid
Vancomycin
Enterococcus faecium
Enterococcus faecalis
Biology
Phage therapy
Enterococcus
Antibiotic resistance
Bacteriophage
Bacteria
Gene
Escherichia coli
Genetics
Staphylococcus aureus
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1128/aac.00740-24
- OA Status
- hybrid
- Cited By
- 5
- References
- 67
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4405570920
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4405570920Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1128/aac.00740-24Digital Object Identifier
- Title
-
In vitro resensitization of multidrug-resistant clinical isolates of Enterococcus faecium and E. faecalis through phage-antibiotic synergyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-12-19Full publication date if available
- Authors
-
Pooja Ghatbale, Govind Prasad Sah, Sage J. B. Dunham, Ethan Khong, Alisha N. Blanc, Alisha N. Monsibais, Andrew Garcia, Robert T. Schooley, Ana G. Cobián-Güemes, Katrine Whiteson, David T. PrideList of authors in order
- Landing page
-
https://doi.org/10.1128/aac.00740-24Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1128/aac.00740-24Direct OA link when available
- Concepts
-
Antibiotics, Microbiology, Linezolid, Vancomycin, Enterococcus faecium, Enterococcus faecalis, Biology, Phage therapy, Enterococcus, Antibiotic resistance, Bacteriophage, Bacteria, Gene, Escherichia coli, Genetics, Staphylococcus aureusTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5Per-year citation counts (last 5 years)
- References (count)
-
67Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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