IL-10 driven memory T cell survival and Tfh differentiation promote HIV persistence Article Swipe
Susan Pereira Ribeiro
,
Malika Aïd
,
Frank P. Dupuy
,
Chi Ngai Chan
,
Judd F. Hultquist
,
Claire Delage
,
Eirini Moysi
,
Deanna A. Kulpa
,
Lianghzu Li
,
Xuan Xu
,
Banumathi Tamilselvan
,
Jeffrey Tomalka
,
Michael Nekorchuk
,
Kathleen Busman‐Sahay
,
Rebeka Bordi
,
Camille R. Simoneau
,
J.P. Goulet
,
Vincent C. Marconi
,
Jean Pierre Routy
,
Robert Balderas
,
Luca Micci
,
Bonnie J. Howell
,
Dan H. Barouch
,
Nevan J. Krogan
,
Constantinos Petrovas
,
Mirko Paiardini
,
Steven G. Deeks
,
Jacob D. Estes
,
Daniel M. Gorman
,
Daria J. Hazuda
,
Rafick‐Pierre Sékaly
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.02.26.432955
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.02.26.432955
Summary Mechanisms regulating HIV persistence are complex and not well understood. Increased IL-10 levels were positively associated with HIV reservoir in blood and lymph nodes (LN) of treated HIV aviremic individuals. In LNs, B cells, regulatory T cells, follicular T helper cells (Tfh), monocytes and macrophages contributed to the frequencies of IL10+ cells. Cells with HIV DNA in LNs were in close proximity to IL-10+ cells and/or had the active form of STAT3, the transcription downstream of IL-10. Gene signatures and proteins associated to cell survival, Co-inhibitory receptors expression, maintenance of memory T cells, immune metabolism and Tfh frequencies were all modulated by IL-10 and associated with HIV reservoir persistence. In vitro, STAT3 knockout or neutralization of IL-10, reverted all the aforementioned pathways and resulted in 10-fold decay in HIV reservoir. Collectively, these results provide strong evidence for a pivotal role of IL-10 in HIV persistence, and a potential therapeutic strategy for HIV cure.
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- Type
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- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.02.26.432955
- https://www.biorxiv.org/content/biorxiv/early/2021/02/26/2021.02.26.432955.full.pdf
- OA Status
- green
- Cited By
- 10
- References
- 120
- Related Works
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- OpenAlex ID
- https://openalex.org/W3134183345
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3134183345Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2021.02.26.432955Digital Object Identifier
- Title
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IL-10 driven memory T cell survival and Tfh differentiation promote HIV persistenceWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-02-26Full publication date if available
- Authors
-
Susan Pereira Ribeiro, Malika Aïd, Frank P. Dupuy, Chi Ngai Chan, Judd F. Hultquist, Claire Delage, Eirini Moysi, Deanna A. Kulpa, Lianghzu Li, Xuan Xu, Banumathi Tamilselvan, Jeffrey Tomalka, Michael Nekorchuk, Kathleen Busman‐Sahay, Rebeka Bordi, Camille R. Simoneau, J.P. Goulet, Vincent C. Marconi, Jean Pierre Routy, Robert Balderas, Luca Micci, Bonnie J. Howell, Dan H. Barouch, Nevan J. Krogan, Constantinos Petrovas, Mirko Paiardini, Steven G. Deeks, Jacob D. Estes, Daniel M. Gorman, Daria J. Hazuda, Rafick‐Pierre SékalyList of authors in order
- Landing page
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https://doi.org/10.1101/2021.02.26.432955Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2021/02/26/2021.02.26.432955.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2021/02/26/2021.02.26.432955.full.pdfDirect OA link when available
- Concepts
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Biology, STAT3, Interleukin 10, Immune system, Immunology, Cytotoxic T cell, Persistence (discontinuity), Transcription factor, Cell biology, Cancer research, In vitro, Signal transduction, Gene, Genetics, Geotechnical engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
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10Total citation count in OpenAlex
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2024: 1, 2023: 4, 2022: 1, 2021: 4Per-year citation counts (last 5 years)
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120Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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