IL-17A promotes epithelial cell IL-33 production during nematode lung migration Article Swipe
Jesuthas Ajendra
,
Stella Pearson
,
James E Parkinson
,
Brian H. K. Chan
,
Henry J. McSorley
,
Tara E. Sutherland
,
Judith E. Allen
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.11.03.515050
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.11.03.515050
The early migratory phase of pulmonary helminth infections is characterized by tissue injury leading to the release of the alarmin IL-33 and subsequent induction of type 2 immune responses. We recently described a role for IL-17A, through regulation of IFNγ, as an important inducer of type 2 responses during infection with the lung-migrating rodent nematode Nippostrongylus brasiliensis . Here, we aimed to investigate the interaction between IL-17A and IL-33 during the early lung migratory stages of N. brasiliensis infection. In this brief report, we demonstrate that deficiency of IL-17A leads to impaired IL-33 expression and secretion early in infection, independent of IL-17A suppression of IFNγ. Impaired IL-33 production was evident in lung epithelial cells, but not innate immune cells. Therefore, our results demonstrate that IL-17A can drive IL-33 during helminth infection, highlighting an additional mechanism through which IL-17A can regulate pulmonary type 2 immunity.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.11.03.515050
- https://www.biorxiv.org/content/biorxiv/early/2022/11/04/2022.11.03.515050.full.pdf
- OA Status
- green
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4308269676
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4308269676Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2022.11.03.515050Digital Object Identifier
- Title
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IL-17A promotes epithelial cell IL-33 production during nematode lung migrationWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-11-04Full publication date if available
- Authors
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Jesuthas Ajendra, Stella Pearson, James E Parkinson, Brian H. K. Chan, Henry J. McSorley, Tara E. Sutherland, Judith E. AllenList of authors in order
- Landing page
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https://doi.org/10.1101/2022.11.03.515050Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2022/11/04/2022.11.03.515050.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2022/11/04/2022.11.03.515050.full.pdfDirect OA link when available
- Concepts
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Nippostrongylus brasiliensis, Immunology, Biology, Immune system, Lung, Secretion, Interleukin 17, Immunity, Interleukin 33, Innate immune system, Cytokine, Interleukin, Cell biology, Medicine, Internal medicine, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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29Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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