IL-33 regulates gene expression in intestinal epithelial cells independently of its nuclear localization Article Swipe
Zhengxiang He
,
Lili Chen
,
Gláucia C. Furtado
,
Sérgio A. Lira
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1101/291039
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1101/291039
IL-33 is a cytokine found in the extracellular space (mature IL-33) or in the cell nucleus (full-length IL-33). Nuclear accumulation of IL-33 has been reported in intestinal epithelial cells (IEC) during intestinal inflammation and cancer, but a functional role for this nuclear form remains unclear. To study the role of nuclear IL-33 in IEC, we generated transgenic mice expressing full-length IL-33 in the intestinal epithelium ( Vfl33 mice). Expression of full-length IL-33 in the epithelium resulted in accumulation of IL-33 protein in the nucleus and secretion of IL-33. Over-expression of full-length IL-33 by IEC did not promote gut inflammation, but induced expression of genes in the IEC and lamina propria lymphocytes (LPL) that correlated negatively with genes expressed in inflammatory bowel diseases (IBD). Because the IL-33 receptor ST2 is expressed by IEC, there was the potential that both the mature and full-length forms could mediate this effect. To specifically interrogate the transcriptional role of nuclear IL-33, we intercrossed the Vfl33 mice with ST2-deficient mice. ST2 deficiency completely abrogated the transcriptional effects elicited by IL-33 expression, suggesting that the transcriptional effects of IL-33 on IEC are mediated by its mature, not its nuclear form. Highlights Expression of full-length IL-33 in the epithelium resulted in accumulation of IL-33 protein in the nucleus and secretion of IL-33. Full-length IL-33 induced differential gene expression in IEC and LPL that was negatively associated with intestinal inflammatory diseases IL-33 regulated gene expression in IEC via its extracellular (mature) form not via its nuclearform.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/291039
- https://www.biorxiv.org/content/biorxiv/early/2018/03/28/291039.full.pdf
- OA Status
- green
- References
- 53
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2949127668
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2949127668Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/291039Digital Object Identifier
- Title
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IL-33 regulates gene expression in intestinal epithelial cells independently of its nuclear localizationWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2018Year of publication
- Publication date
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2018-03-28Full publication date if available
- Authors
-
Zhengxiang He, Lili Chen, Gláucia C. Furtado, Sérgio A. LiraList of authors in order
- Landing page
-
https://doi.org/10.1101/291039Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2018/03/28/291039.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2018/03/28/291039.full.pdfDirect OA link when available
- Concepts
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Lamina propria, Intestinal epithelium, Biology, Inflammation, Epithelium, Secretion, Cell biology, Gene expression, Cell nucleus, Cytokine, Nucleus, Interleukin 33, Molecular biology, Gene, Interleukin, Immunology, Endocrinology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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53Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2157710399, https://openalex.org/W2043099698, https://openalex.org/W2166623795, https://openalex.org/W2078136106, https://openalex.org/W2136348136, https://openalex.org/W2020887684, https://openalex.org/W1997308986, https://openalex.org/W2168452283, https://openalex.org/W2025670550, https://openalex.org/W2078489088, https://openalex.org/W2121674630, https://openalex.org/W2085375952, https://openalex.org/W2110115488, https://openalex.org/W2131180975, https://openalex.org/W2735710638, https://openalex.org/W2270215994, https://openalex.org/W2049897075, https://openalex.org/W2069526125, https://openalex.org/W2019546252, https://openalex.org/W2069609111, https://openalex.org/W2073666097, https://openalex.org/W2123268015, https://openalex.org/W2053735133, https://openalex.org/W2086746877, https://openalex.org/W2103740237, https://openalex.org/W2114330412, https://openalex.org/W1994530174, https://openalex.org/W2169589032, https://openalex.org/W2159675211, https://openalex.org/W2097065948, https://openalex.org/W2134526812, https://openalex.org/W2130116522, https://openalex.org/W2114104545, https://openalex.org/W2618676341, https://openalex.org/W2340320569, https://openalex.org/W2087869886, https://openalex.org/W2059494963, https://openalex.org/W2084575069, https://openalex.org/W2211380301, https://openalex.org/W2077132509, https://openalex.org/W1530611653, https://openalex.org/W2588282652, https://openalex.org/W2604469506, https://openalex.org/W2594848814, https://openalex.org/W2730503811, https://openalex.org/W1993954065, https://openalex.org/W2093396768, https://openalex.org/W2148174710, https://openalex.org/W2144563711, https://openalex.org/W2057190795, https://openalex.org/W2528879414, https://openalex.org/W2087778794, https://openalex.org/W2072072704 |
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