IL-8 and IL-1RA serum levels predicting depression treatment response in 6-week follow-up Article Swipe
Tuukka Mökkönen
,
Anssi Solismaa
,
Mari Hämäläinen
,
Eeva Moilanen
,
Olli Kampman
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1017/neu.2025.10027
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1017/neu.2025.10027
Objective: This study aims to ascertain the effect of baseline IL-1Ra and IL-8 in the treatment response of patients with major depressive disorder (MDD) and to clarify the relationship between inflammation markers and depression. Methods: We recruited 242 patients with a Beck Depression Inventory (BDI) score ≥ 17 referred to secondary care in Finland. The patients’ serum IL-1Ra and IL-8 concentrations were measured at baseline. Montgomery-Åsberg Depression Rating Scale (MADRS) tests and Alcohol Use Disorders Identification Tests (AUDIT) were administered at baseline and six weeks. The antidepressant treatments varied: somewere started, others changed or continued their previous medication, and others had their doses adjusted. Patients started behavioral activation therapy. Linear regression was used with a relative MADRS score change during six weeks as the dependent variable and patient age, AUDIT score, BMI, daily number of cigarettes smoked, sex, and serum IL-1Ra and IL-8 concentrations as independent variables. Results: Higher baseline serum IL-1Ra and IL-8 levels were associated with a smaller relative change in the MADRS-score within the first six weeks of treatment in linear regression analysis ( p < 0.001 and p = 0.007, respectively). In further analysis comparing groups with ≤ 24 and>24 MADRS score only the ≤ 24 MADRS score group showed a similar association. Conclusion: Higher baseline IL-1Ra and IL-8 concentrations were associated with a lesser relative response to depression treatment, particularly in patients with mild depression. Results on IL-8 concur with earlier findings, whereas the association between higher IL-1Ra serum concentrations reduced treatment response is a novel finding.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1017/neu.2025.10027
- https://www.cambridge.org/core/services/aop-cambridge-core/content/view/2A29C78D0E4ED19B36B7A2625C182053/S0924270825100276a.pdf/div-class-title-il-8-and-il-1ra-serum-levels-predicting-depression-treatment-response-in-6-week-follow-up-div.pdf
- OA Status
- hybrid
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412097692
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4412097692Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1017/neu.2025.10027Digital Object Identifier
- Title
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IL-8 and IL-1RA serum levels predicting depression treatment response in 6-week follow-upWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-01Full publication date if available
- Authors
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Tuukka Mökkönen, Anssi Solismaa, Mari Hämäläinen, Eeva Moilanen, Olli KampmanList of authors in order
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https://doi.org/10.1017/neu.2025.10027Publisher landing page
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https://www.cambridge.org/core/services/aop-cambridge-core/content/view/2A29C78D0E4ED19B36B7A2625C182053/S0924270825100276a.pdf/div-class-title-il-8-and-il-1ra-serum-levels-predicting-depression-treatment-response-in-6-week-follow-up-div.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
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https://www.cambridge.org/core/services/aop-cambridge-core/content/view/2A29C78D0E4ED19B36B7A2625C182053/S0924270825100276a.pdf/div-class-title-il-8-and-il-1ra-serum-levels-predicting-depression-treatment-response-in-6-week-follow-up-div.pdfDirect OA link when available
- Concepts
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Depression (economics), Internal medicine, Medicine, Beck Depression Inventory, Major depressive disorder, Rating scale, Psychology, Psychiatry, Anxiety, Macroeconomics, Developmental psychology, Economics, AmygdalaTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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26Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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